2001 年至 2022 年类风湿关节炎 microRNAs 的文献计量分析：研究热点和趋势。
A bibliometric analysis of miRNAs in rheumatoid arthritis from 2001 to 2022: Research hotspots and trends.
机构信息
Department of Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Wuxi, China.
出版信息
Int J Rheum Dis. 2024 Apr;27(4):e15121. doi: 10.1111/1756-185X.15121.
BACKGROUND
MicroRNAs (miRNAs) are widely recognized in the pathogenesis of autoimmune disease. As a key regulatory factor, miRNAs have introduced new biomarkers for the early diagnosis of rheumatoid arthritis (RA) and provided a favorable research direction for the development of novel therapeutic targets. This study aimed to explore the hotspots of miRNA research related to RA published from different countries, organizations, and authors.
METHODS
From 2001 to 2022, publications on miRNA related to RA were identified in the Web of Science database. The total and annual number of publishments, citations, impact factor, H-index, productive authors, and involved journals were collected for quantitative and qualitative comparisons.
RESULTS
A total of 29 countries/regions in the world have participated in the research of miRNAs and RA over the past two decades, and China (760, 53.18%) and the United States (233, 16.31%) account for the majority of the total publications. China dominated in total citation (17881) and H-index (62). A total of 507 academic journals have published articles in related fields, and Frontiers in Immunology published the most (53, 3.71%). Chih-hsin Tang of the China Medical University has published the most papers (16, 1.2%). Stanczyk (2008) published the most cited article Altered expression of miRNAs in synovial fibroblasts and synovial tissue in rheumatoid arthritis in Arthritis and Rheumatism, with 660 citations. Inflammation is the high-frequency keyword outside of RA and miRNAs, and related researches have mainly focused on miR-146a and miR-155.
CONCLUSIONS
In the past two decades, extensive and continuous research has been conducted to investigate the role of miRNAs in RA, and miRNAs are widely recognized in the pathogenesis of RA. Related research has mainly focused on miR-146a and miR-155 that have shown promising results as key factors in RA experimental models. Focusing on clinical applications and translational research may be the future research direction and hotspot based on molecular biology basic research and mechanism exploration.
背景
MicroRNAs（miRNAs）在自身免疫性疾病的发病机制中得到了广泛认可。作为关键调控因子，miRNAs 为类风湿关节炎（RA）的早期诊断引入了新的生物标志物，并为新型治疗靶点的开发提供了有利的研究方向。本研究旨在探讨来自不同国家、组织和作者的与 RA 相关的 miRNA 研究热点。
方法
从 2001 年到 2022 年，在 Web of Science 数据库中确定了与 RA 相关的 miRNA 出版物。收集了出版物总数和年发表量、引用次数、影响因子、H 指数、高产作者和涉及的期刊，进行定量和定性比较。
结果
在过去的二十年中，全球共有 29 个国家/地区参与了 miRNA 和 RA 的研究，中国（760 篇，53.18%）和美国（233 篇，16.31%）占总出版物的大部分。中国在总引用量（17881）和 H 指数（62）方面占据主导地位。共有 507 种学术期刊发表了相关领域的文章，Frontiers in Immunology 发表的文章最多（53 篇，3.71%）。中国医药大学的 Chih-hsin Tang 发表的文章最多（16 篇，1.2%）。Stanczyk（2008）在 Arthritis and Rheumatism 上发表的被引频次最高的文章是“Altered expression of miRNAs in synovial fibroblasts and synovial tissue in rheumatoid arthritis”，引用次数为 660 次。炎症是除 RA 和 miRNAs 之外的高频关键词，相关研究主要集中在 miR-146a 和 miR-155 上。
结论
在过去的二十年中，广泛而持续的研究已经开展，以探讨 miRNAs 在 RA 中的作用，并且 miRNAs 在 RA 的发病机制中得到了广泛认可。相关研究主要集中在 miR-146a 和 miR-155 上，这些 miRNA 作为 RA 实验模型中的关键因素显示出了有前景的结果。基于分子生物学基础研究和机制探索，关注临床应用和转化研究可能是未来的研究方向和热点。
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