Bai Lu, Yang Pengjie, Han Bater, Kong Linghui
Inner Mongolia Medical University, Hohhot, China.
Department of Pathology, Peking University Cancer Hospital & Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, China.
Front Oncol. 2024 Mar 18;14:1374094. doi: 10.3389/fonc.2024.1374094. eCollection 2024.
In recent years, the acyl-Coenzyme A thioester hydrolase family (ACOTs) has received wide attention as a key link in lipid metabolism. This family is a class of enzymes that catalyze the hydrolysis of fatty acyl-Coenzyme A, disrupting the thioester bond present within acyl-CoA ester molecules to produce free fatty acids (FFA) and the corresponding coenzyme A (CoA). Such enzymes play a very important role in lipid metabolism through maintaining appropriate levels of intracellular FFA and fatty acyl-CoA as well as CoA. It is broadly divided into two distinct subgroups, the type-I α/β-hydrolase fold enzyme superfamily and the type-II 'hot dog' fold superfamily. There are currently four human type-I genes and eight human type-II genes. Although the two subgroups catalyze the same reaction, they are not structurally similar, do not share the same sequence homology, and differ greatly in protein executive functions. This review summarizes the classification of the acyl-CoA thioester hydrolase family, an overview of the structural sequences, and advances in digestive, respiratory, and urinary systemic tumors. In order to explore potential specific drug targets and effective interventions, to provide new strategies for tumor prevention and treatment.
近年来，酰基辅酶A硫酯水解酶家族（ACOTs）作为脂质代谢的关键环节受到广泛关注。该家族是一类催化脂肪酰基辅酶A水解的酶，破坏酰基辅酶A酯分子中的硫酯键，生成游离脂肪酸（FFA）和相应的辅酶A（CoA）。这类酶通过维持细胞内FFA、脂肪酰基辅酶A以及CoA的适当水平，在脂质代谢中发挥着非常重要的作用。它大致分为两个不同的亚组，即I型α/β水解酶折叠酶超家族和II型“热狗”折叠超家族。目前有四个人类I型基因和八个人类II型基因。尽管这两个亚组催化相同的反应，但它们在结构上不相似，不具有相同的序列同源性，并且在蛋白质执行功能上有很大差异。本综述总结了酰基辅酶A硫酯水解酶家族的分类、结构序列概述以及在消化、呼吸和泌尿系统肿瘤方面的研究进展。旨在探索潜在的特异性药物靶点和有效的干预措施，为肿瘤的预防和治疗提供新策略。
