A Porphyrin-Based 3D Metal-Organic Framework Featuring [CuCl] Cluster Secondary Building Units: Synthesis, Structure Elucidation, Anion Exchange, and Peroxidase-Like Activity.

Herein, we report a rare example of cationic three-dimensional (3D) metal-organic framework (MOF) of [CuCl(TMPP)]Cl ⋅ xSol (denoted as Cu-TMPP; HTMPP=meso-tetrakis (6-methylpyridin-3-yl) porphyrin; xSol=encapsulated solvates) supported by [CuCl] cluster secondary building units (SBUs) wherein the eight faces of the Cl-based octahedron are capped by eight Cu. Surface-area analysis indicated that Cu-TMPP features a mesoporous structure and its solvate-like Cl counterions can be exchanged by BF , PF , and NO . The polyvinylpyrrolidone (PVP) coated Cu-TMPP (denoted as Cu-TMPP-PVP) demonstrated good ROS generating ability, producing ⋅OH in the absence of light (peroxidase-like activity) and O on light irradiation (650 nm; 25 mW cm). This work highlights the potential of Cu-TMPP as a functional carrier of anionic guests such as drugs, for the combination therapy of cancer and other diseases.