Paediatric Infectious Diseases.
Department of Microbiology, Laboratory Medicine.
Pediatr Infect Dis J. 2024 Aug 1;43(8):772-776. doi: 10.1097/INF.0000000000004347. Epub 2024 Apr 2.
Cefiderocol, a novel siderophore cephalosporin, represents a treatment option for infections with multidrug-resistant Gram-negative bacteria, of which rates are rising worldwide. Clinical data on its use in children is limited. In our pediatric case series, the largest reported to date, cefiderocol seems safe and well tolerated, with more favorable clinical outcomes when compared to the literature reviewing adult cases.
头孢他啶-多利培南,一种新型的铁载体头孢菌素,为治疗对多种药物耐药的革兰氏阴性菌感染提供了一种选择。目前,这种药物在全球的耐药率正在不断上升。关于该药在儿童中的应用,目前仅有有限的临床数据。在我们的儿科病例系列中,这是迄今为止报告的最大病例系列,与文献中回顾的成人病例相比,头孢他啶-多利培南似乎更安全,耐受性更好,临床结局也更有利。