前列腺素在周期性雌性大鼠黄素化未破裂卵泡形成中的作用。

Prostaglandins involvement in the formation of luteinized unruptured follicles in the cyclic female rat.

作者信息

Plas-Roser S, Kauffmann M T, Aron C

出版信息

Prostaglandins. 1985 Feb;29(2):243-53. doi: 10.1016/0090-6980(85)90205-9.

Abstract

The purpose of this investigation was to study the role played by prostaglandins in advanced ovulation and in the formation of luteinized unruptured follicles (LUF) in cyclic female rats. Dose related effects on ovulation were observed in rats given LH on diestrus 2 at 16.30. A significant positive correlation was observed between the number of postovulatory corpora lutea (POCL) and the increasing doses of LH. By contrast the number of LUF was negatively correlated with LH. Indomethacin treatment by 6h30 after administration of an ovulatory LH dose significantly increased the occurrence of LUF at the expense of POCL. Conversely PGF2 alpha when administered by 6h30 after a subovulatory LH stimulation enhanced in a dose dependent manner the number of POCL with respect to the LH treated controls. Under a similar treatment with a subovulatory dose of LH, PGE2 remained without ovulatory effects. The mechanisms of the formation of LUF are discussed on the basis of these results.

摘要

本研究的目的是探讨前列腺素在雌性大鼠发情周期中排卵延迟及黄素化未破裂卵泡（LUF）形成过程中所起的作用。在动情周期第2天16:30给予促黄体生成素（LH）的大鼠中，观察到了剂量相关的排卵效应。排卵后黄体（POCL）数量与LH剂量增加呈显著正相关。相比之下，LUF数量与LH呈负相关。在给予排卵剂量的LH后6:30用吲哚美辛处理，以POCL数量减少为代价，显著增加了LUF的发生率。相反，在给予低于排卵剂量的LH刺激后6:30给予前列腺素F2α（PGF2α），相对于LH处理的对照组，以剂量依赖的方式增加了POCL的数量。在给予低于排卵剂量的LH的类似处理下，前列腺素E2（PGE2）没有排卵效应。基于这些结果，对LUF的形成机制进行了讨论。