Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
International Medical Service Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China.
BMC Cardiovasc Disord. 2024 Apr 3;24(1):191. doi: 10.1186/s12872-024-03867-2.
To examine the prognostic value of superoxide dismutase (SOD) activity for monitoring reduced left ventricular ejection fraction(LVEF)in the patients with type 2 diabetes and acute coronary syndrome (ACS).
The population of this cross-sectional study included 2377 inpatients with type 2 diabetes who had an ACS admitted to the Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2016 to January 2021.
Diabetic patients with ACS were divided into 2 subgroups based on LVEF. The mean SOD activity was significantly lower in patients with an LVEF ≤ 45% than in those with an LVEF > 45% (149.1 (146.4, 151.9) versus 161.9 (160.8, 163.0)). Using ROC statistic, a cut-off value of 148.8 U/ml indicated an LVEF ≤ 45% with a sensitivity of 51.6% and a specificity of 73.7%. SODs activity were found to be correlated with the levels of NT-proBNP, hs-cTnT, the inflammatory marker CRP and fibrinogen. Despite taking the lowest quartile as a reference (OR 0.368, 95% CI 0.493-0.825, P = 0.001) or examining 1 normalized unit increase (OR 0.651, 95% CI 0.482-0.880, P = 0.005), SOD activity was found to be a stronger predictor of reduced LVEF than CRP and fibrinogen, independent of confounding factors.
Our cross-sectional study suggests that SOD activity might be a valuable and easily accessible tool for assessing and monitoring reduced LVEF in the diabetic patients with ACS.
探讨超氧化物歧化酶（SOD）活性对监测 2 型糖尿病合并急性冠状动脉综合征（ACS）患者左心室射血分数（LVEF）降低的预后价值。
本横断面研究的研究人群包括 2016 年 1 月至 2021 年 1 月期间因 ACS 入住山东第一医科大学附属省立医院的 2377 例 2 型糖尿病住院患者。
根据 LVEF 将 ACS 合并糖尿病患者分为 2 亚组。LVEF≤45%的患者 SOD 活性明显低于 LVEF＞45%的患者（149.1（146.4，151.9）与 161.9（160.8，163.0））。使用 ROC 统计，截点值为 148.8 U/ml 时，LVEF≤45%的敏感性为 51.6%，特异性为 73.7%。SOD 活性与 NT-proBNP、hs-cTnT、炎症标志物 CRP 和纤维蛋白原水平相关。尽管将最低四分位数作为参考（OR 0.368，95%CI 0.493-0.825，P=0.001）或检查 1 个单位的标准化增加（OR 0.651，95%CI 0.482-0.880，P=0.005），SOD 活性是预测 LVEF 降低的更强指标，独立于混杂因素。
本横断面研究表明，SOD 活性可能是评估和监测 2 型糖尿病合并 ACS 患者 LVEF 降低的一种有价值且易于获得的工具。
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