阐明细胞表面组以加速癌症药物开发。
Elucidating the Cell Surfaceome to Accelerate Cancer Drug Development.
机构信息
Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York.
Reveal Therapeutics, Inc., New York, New York.
出版信息
Cancer Discov. 2024 Apr 4;14(4):639-642. doi: 10.1158/2159-8290.CD-24-0088.
Cell surface proteins represent ideal therapeutic targets because of their accessibility to antibodies, T cell-directed therapies, and radiotherapies, but there are only 25 therapeutically relevant cell surface targets for which cancer therapies are approved in the United States or European Union. This commentary calls for intensified research into mapping the universe of cell surface proteins - the cell surfaceome - in order to accelerate cancer drug development.
细胞表面蛋白是理想的治疗靶点，因为它们可以与抗体、T 细胞导向疗法和放射疗法结合使用，但是，在美国或欧盟批准的癌症治疗方法中，仅有 25 个具有治疗意义的细胞表面靶点。本文评论呼吁加强对细胞表面蛋白（细胞表面组）的研究，以加速癌症药物的开发。
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