Zhang Yu-Xin, Zhang Yan-Jiao, Li Min, Tian Jia-Xing, Tong Xiao-Lin
Institute of Metabolic Diseases, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
J Neurogastroenterol Motil. 2024 Apr 30;30(2):143-155. doi: 10.5056/jnm23100.
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients. Research on the relationship between gastrointestinal dynamics and DGP has received much attention because of the increasing prevalence of DGP. Gastrointestinal motility disorders are closely related to a variety of factors including the absence and destruction of interstitial cells of Cajal, abnormalities in the neuro-endocrine system and hormone levels. Therefore, this study will review recent literature on the mechanisms of DGP and gastrointestinal motility disorders as well as the development of prokinetic treatment of gastrointestinal motility disorders in order to give future research directions and identify treatment strategies for DGP.
糖尿病性胃轻瘫（DGP）是糖尿病的常见并发症，其特征为胃肠动力障碍，即存在胃排空延迟且无机械性梗阻。临床表现包括餐后饱胀、上腹部不适、腹胀、恶心和呕吐。DGP可显著影响患者的生活质量和生产力。由于DGP的患病率不断上升，关于胃肠动力学与DGP之间关系的研究受到了广泛关注。胃肠动力障碍与多种因素密切相关，包括Cajal间质细胞的缺失和破坏、神经内分泌系统异常以及激素水平异常。因此，本研究将综述近期关于DGP和胃肠动力障碍机制以及胃肠动力障碍促动力治疗进展的文献，以便给出未来的研究方向并确定DGP的治疗策略。
