Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Department of Pediatrics, Minami-Nara General Medical Center, 8-1 Hukugami, Oyodo-cho, Yosino, Nara, 638-8551, Japan.
CEN Case Rep. 2024 Dec;13(6):463-467. doi: 10.1007/s13730-024-00875-1. Epub 2024 Apr 6.
Most peritoneal dialysis (PD)-associated infections caused by Mycobacterium abscessus (M. abscessus) require a transfer from PD to hemodialysis (HD). Here, we report a pediatric case of exit-site and tunnel infections caused by M. abscessus, for whom PD was continued with catheter replacement, debridement of the infected site, and the administration of multiple antibacterial agents. A 10-year-old boy with end-stage kidney disease secondary to juvenile nephronophthisis with NPHP1 deletion, for whom PD was initiated at the age of 9 years, was admitted to the hospital with complaints of fever, pus at the exit-site of the PD catheter, and poor PD drainage. The dialysis effluent culture results were negative; however, M. abscessus was detected in the pus at the exit-site of the PD catheter. The management of HD was expected to be challenging owing to the presence of developmental disorders. Therefore, PD was continued with the simultaneous removal of the PD catheter, reinsertion of a new catheter at a new site, and debridement of the infected site. Multiple antibacterial therapies were administered for 2 months, and the patient was eventually discharged without switching to HD. To the best of our knowledge, this is the first pediatric case of a PD-associated infection caused by M. abscessus, for whom PD was continued without switching to HD. This treatment strategy is not generally recommended but may be an option for patients without peritonitis who have difficulty switching to HD.
大多数由脓肿分枝杆菌(M. abscessus)引起的腹膜透析(PD)相关感染需要从 PD 转为血液透析(HD)。在这里,我们报告了一例由脓肿分枝杆菌引起的出口部位和隧道感染的儿科病例,该病例通过更换导管、清创感染部位和使用多种抗菌药物继续进行 PD 治疗。一名 10 岁男孩因青少年肾单位肾痨伴 NPHP1 缺失导致终末期肾病,9 岁时开始进行 PD,因发热、PD 导管出口部位有脓液和 PD 引流不畅而入院。透析液培养结果为阴性;然而,在 PD 导管出口部位的脓液中检测到了脓肿分枝杆菌。由于存在发育障碍,预计 HD 管理会很困难。因此,同时拔除 PD 导管,在新部位重新插入新导管,并清创感染部位,继续 PD 治疗。给予多种抗菌治疗 2 个月后,患者最终未转 HD 出院。据我们所知,这是首例由脓肿分枝杆菌引起的 PD 相关感染的儿科病例,该病例继续 PD 治疗而未转 HD。这种治疗策略通常不被推荐,但对于没有腹膜炎且难以转 HD 的患者可能是一种选择。