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旁观者干预对异物气道梗阻患者生存和神经结局的影响:MOCHI 注册研究结果。

The effects of bystander interventions for foreign body airway obstruction on survival and neurological outcomes: Findings of the MOCHI registry.

机构信息

Department of Emergency Medicine, University of New Mexico, USA; Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Department of Emergency and Critical Care Medicine, Nippon Medical School Hospital Tokyo, Japan.

出版信息

Resuscitation. 2024 Jun;199:110198. doi: 10.1016/j.resuscitation.2024.110198. Epub 2024 Apr 4.

Abstract

INTRODUCTION

Foreign body airway obstruction (FBAO) is a life-threatening condition. We aimed to quantify the impact of bystander FBAO interventions on survival and neurological outcomes.

METHODS

We conducted a Japan-wide prospective, multi-center, observational study including all FBAO patients who presented to the Emergency Department from April 2020 to March 2023. Information on bystander FBAO interventions was collected through interviews with emergency medical services personnel. Primary outcomes included 1-month survival and favorable neurologic outcome defined as Cerebral Performance Category 1 or 2. We performed a multivariable logistic regression and a Cox proportional hazards modeling to adjust for confounders.

RESULTS

We analyzed a total of 407 patients in the registry who had the median age of 82 years old (IQR 73-88). The FBAO incidents were often witnessed (86.5%, n = 352/407) and the witnesses intervened in just over half of the cases (54.5%, n = 192/352). The incidents frequently occurred at home (54.3%, n = 221/407) and nursing home (21.6%, n = 88/407). Common first interventions included suction (24.8%, n = 101/407) and back blow (20.9%, n = 85/407). The overall success rate of bystander interventions was 48.4% (n = 93/192). About half (48.2%, n = 196/407) survived to 1-month and 23.8% patients (n = 97/407) had a favorable neurological outcome. Adjusting for pre-specified confounders, bystander interventions were independently associated with survival (hazard ratio, 0.55; 95% CI, 0.39-0.77) and a favorable neurological outcome (adjusted OR, 2.18; 95% CI, 1.23-3.95).

CONCLUSION

Bystander interventions were independently associated with survival and favorable neurological outcome, however, they were performed only in the half of patients.

摘要

介绍

异物气道阻塞(FBAO)是一种危及生命的情况。我们旨在量化旁观者 FBAO 干预对生存和神经结局的影响。

方法

我们进行了一项日本全国范围的前瞻性、多中心、观察性研究,纳入了 2020 年 4 月至 2023 年 3 月期间到急诊科就诊的所有 FBAO 患者。通过与急救医疗服务人员的访谈收集了旁观者 FBAO 干预措施的信息。主要结局包括 1 个月的生存率和良好的神经功能结局,定义为脑功能状态分类 1 或 2 级。我们进行了多变量逻辑回归和 Cox 比例风险模型分析,以调整混杂因素。

结果

我们对登记册中的 407 名患者进行了分析,中位年龄为 82 岁(IQR 73-88)。FBAO 事件通常有目击者(86.5%,n=352/407),只有一半以上的目击者进行了干预(54.5%,n=192/352)。事件常发生在家庭(54.3%,n=221/407)和养老院(21.6%,n=88/407)。常见的初步干预措施包括抽吸(24.8%,n=101/407)和背部冲击(20.9%,n=85/407)。旁观者干预的总体成功率为 48.4%(n=93/192)。约一半(48.2%,n=196/407)患者在 1 个月时存活,23.8%的患者(n=97/407)有良好的神经功能结局。调整预先指定的混杂因素后,旁观者干预与生存(风险比,0.55;95%CI,0.39-0.77)和良好的神经功能结局(调整后的 OR,2.18;95%CI,1.23-3.95)独立相关。

结论

旁观者干预与生存和良好的神经功能结局独立相关,但仅在一半的患者中进行。

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