Antonios Kais, Shaheen Aciel, Dutta Priyata, Fine Michael
Internal Medicine, Trinity Health Ann Arbor Hospital, Ann Arbor, USA.
Gastroenterology, Trinity Health Ann Arbor Hospital, Ann Arbor, USA.
Cureus. 2024 Mar 7;16(3):e55717. doi: 10.7759/cureus.55717. eCollection 2024 Mar.
Because of the variety of drugs, herbal, and dietary supplements used in clinical practice. Drug-induced liver injury (DILI) has become an important and common cause of acute liver injury and failure. Many drugs associated with DILI have been identified, but there remains some uncertainty about others. Cyclophosphamide is a commonly used antineoplastic medication, and its association with DILI has been reported in animals and has been established in humans with the use of high-dose IV. Oral cyclophosphamide has not been clearly shown to cause acute liver injury, thus highlighting many of the unique aspects of this manuscript. Here, we report a case of cyclophosphamide-induced DILI with the aim to alert clinicians regarding this potential association.
由于临床实践中使用的药物、草药和膳食补充剂种类繁多，药物性肝损伤（DILI）已成为急性肝损伤和肝衰竭的重要且常见原因。许多与DILI相关的药物已被确定，但其他一些药物仍存在不确定性。环磷酰胺是一种常用的抗肿瘤药物，其与DILI的关联在动物中已有报道，在人类使用高剂量静脉注射时也已得到证实。口服环磷酰胺尚未明确显示会导致急性肝损伤，因此突出了本手稿的许多独特之处。在此，我们报告一例环磷酰胺诱导的DILI病例，旨在提醒临床医生注意这种潜在关联。
