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创伤管理中主动脉内复苏球囊阻断术:临床适应症及挑战的综合研究

Resuscitative endovascular balloon occlusion of the aorta in trauma management: a comprehensive study of clinical indications and challenges.

作者信息

Wannatoop Tongporn, Phuangphung Peerayuht, Sornmanapong Tanut

机构信息

Department of Surgery, Mahidol University, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

Department of Forensic Medicine, Mahidol University, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

出版信息

Trauma Surg Acute Care Open. 2024 Apr 3;9(1):e001264. doi: 10.1136/tsaco-2023-001264. eCollection 2024.

Abstract

BACKGROUND

The application of resuscitative endovascular balloon occlusion of the aorta (REBOA) in trauma resuscitation, including for profound shock and cardiac arrest, has gained prominence. This study aimed to determine the characteristics of patients who were transported to the trauma resuscitation area (the TTRA group) and those who died at the scene (the DAS group), aiming to identify suitable REBOA candidates and critical contraindications.

METHODS

A descriptive research design was used. We retrospectively reviewed 1158 adult trauma patients managed at a level I trauma center in 2020 and 2021. The TTRA group comprised 215 patients who, upon arrival at the trauma resuscitation area, either presented with a systolic blood pressure under 90 mm Hg or were in traumatic cardiac arrest but still exhibited signs of life. The study included patients directly transferred from incident scenes to the forensic unit. The DAS group comprised 434 individuals who were declared deceased at the scene of major trauma. REBOA indications were considered for two purposes: anatomic bleeding control for sources below the diaphragm to the groin, and circulatory restoration in patients with profound shock or cardiac arrest. Absolute REBOA contraindications were assessed, particularly for aortic and cardiac injuries, with or without cardiac tamponade.

RESULTS

Predominantly male, the cohort largely consisted of motorcycle accident victims. The median Injury Severity Score was 41 (range 1-75). Within the TTRA group, the prospective applicability of REBOA was 52.6%, with a prevalence of major hemorrhagic sources from the abdomen to the groin of 38.6% and substantial intra-abdominal bleeding of 28.8%. The DAS group exhibited a prevalence of major hemorrhagic sources from the abdomen to the groin of 50.2%, and substantial intra-abdominal bleeding of 41.2%. In terms of REBOA contraindications, the DAS group demonstrated a greater prevalence of overall contraindications of 25.8%, aortic injuries 17.3%, and concomitant conditions of 16.4%. In the TTRA group, the rates of overall contraindications, aortic injury, and comorbid conditions were 12.6%, 4.2%, and 8.8, respectively. Cardiac injuries were noted in approximately 10% of patients in both groups.

CONCLUSIONS

This investigation underscores the potential benefits of REBOA in the management of major trauma patients. The prevalence of bleeding sources suitable for REBOA was high in both the TTRA and DAS groups. However, a significant number of patients in both groups also had contraindications to the procedure. These outcomes highlight the critical importance of enhanced training in patient assessment to ensure the safe and effective deployment of REBOA, particularly in resource-limited environments such as ongoing trauma resuscitation and prehospital care.

LEVEL OF EVIDENCE

Level III.

摘要

背景

主动脉内复苏球囊阻断术(REBOA)在创伤复苏中的应用,包括用于严重休克和心脏骤停,已受到广泛关注。本研究旨在确定被转运至创伤复苏区域的患者(创伤复苏区域组)和在现场死亡的患者(现场死亡组)的特征,以确定合适的REBOA候选者和关键禁忌证。

方法

采用描述性研究设计。我们回顾性分析了2020年和2021年在一级创伤中心接受治疗的1158例成年创伤患者。创伤复苏区域组包括215例患者,这些患者在到达创伤复苏区域时,收缩压低于90 mmHg,或处于创伤性心脏骤停但仍有生命体征。研究包括直接从事故现场转运至法医部门的患者。现场死亡组包括434例在重大创伤现场被宣布死亡的个体。考虑REBOA适应证有两个目的:控制膈肌以下至腹股沟部位的解剖学出血,以及恢复严重休克或心脏骤停患者的循环。评估了绝对REBOA禁忌证,特别是对于有无心包填塞的主动脉和心脏损伤。

结果

该队列以男性为主,主要由摩托车事故受害者组成。损伤严重度评分中位数为41分(范围1 - 75分)。在创伤复苏区域组中,REBOA的预期适用率为52.6%,腹部至腹股沟主要出血源的发生率为38.6%,腹腔内大量出血的发生率为28.8%。现场死亡组腹部至腹股沟主要出血源的发生率为50.2%,腹腔内大量出血的发生率为41.2%。在REBOA禁忌证方面,现场死亡组总体禁忌证的发生率更高,为25.8%,主动脉损伤为17.3%,合并症为16.4%。在创伤复苏区域组中,总体禁忌证、主动脉损伤和合并症的发生率分别为12.6%、4.2%和8.8%。两组中约10%的患者有心脏损伤。

结论

本调查强调了REBOA在重大创伤患者管理中的潜在益处。创伤复苏区域组和现场死亡组中适合REBOA的出血源发生率都很高。然而,两组中都有相当数量的患者存在该手术的禁忌证。这些结果凸显了加强患者评估培训以确保安全有效地应用REBOA的至关重要性,特别是在如正在进行的创伤复苏和院前急救等资源有限的环境中。

证据水平

三级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/90b0/11002364/0a3a86695a1a/tsaco-2023-001264f01.jpg

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