Mokler D J, Stoudt K W, Rech R H
Pharmacol Biochem Behav. 1985 May;22(5):677-82. doi: 10.1016/0091-3057(85)90512-x.
Indolealkylamine and phenethylamine hallucinogens disrupted responding maintained under a fixed-ratio 40 (FR-40) schedule of reinforcement. LSD, DMT, mescaline and DOM produced dose-dependent decreases in number of reinforcers and increases in 10-sec periods of non-responding (pause-intervals). The 5HT agonist quipazine, as well as the LSD congener lisuride, altered response patterns in a similar manner. The effects of these drugs were examined after pretreatment with pirenperone, an antagonist with specificity toward the 5HT2 receptor with reference to the 5HT1 receptor. The dose-response curves for the phenethylamine hallucinogens were shifted significantly to the right and to a greater degree than were those for the indolealkylamine hallucinogens. Pirenperone also antagonized the effects of quipazine to a degree similar to that observed with the phenethylamine-type hallucinogens. Pirenperone did not significantly shift the dose-response pattern to lisuride. These data suggest that the behavioral disruption induced by these hallucinogens and quipazine relates at least in part to an effect on 5HT2 receptors, while the effects of lisuride do not involve a significant interaction at the 5HT2 receptor.
吲哚烷基胺和苯乙胺类致幻剂破坏了在固定比率40（FR - 40）强化程序下维持的反应。麦角酸二乙酰胺（LSD）、二甲基色胺（DMT）、三甲氧苯乙胺（mescaline）和2,5 - 二甲氧基 - 4 - 甲基苯丙胺（DOM）使强化物数量呈剂量依赖性减少，并使10秒无反应期（暂停间隔）增加。5 - 羟色胺（5HT）激动剂喹哌嗪以及LSD同系物麦角酰二乙胺（lisuride）以类似方式改变反应模式。在用哌迷清（一种对5HT2受体具有相对于5HT1受体特异性的拮抗剂）预处理后，研究了这些药物的作用。苯乙胺类致幻剂的剂量 - 反应曲线显著右移，且比吲哚烷基胺类致幻剂的右移程度更大。哌迷清对喹哌嗪作用的拮抗程度与对苯乙胺类致幻剂观察到的程度相似。哌迷清未显著改变麦角酰二乙胺的剂量 - 反应模式。这些数据表明，这些致幻剂和喹哌嗪引起的行为破坏至少部分与对5HT2受体的作用有关，而麦角酰二乙胺的作用在5HT2受体处不涉及显著相互作用。
