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慢性髓性白血病患者停用酪氨酸激酶抑制剂 3 次后行冻融胚胎移植成功妊娠并分娩

Successful Pregnancy and Delivery after Frozen-thawed Embryo Transfer Following the Third Discontinuation of Tyrosine Kinase Inhibitor in a Woman with Chronic Myeloid Leukemia.

机构信息

Department of Hematology, Yokohama City University Medical Center, Japan.

Reproductive Medicine Center, Yokohama City University Medical Center, Japan.

出版信息

Intern Med. 2024 Dec 1;63(23):3233-3236. doi: 10.2169/internalmedicine.3322-23. Epub 2024 Apr 9.

Abstract

Assisted reproductive technology is a viable option for pregnant women with chronic myeloid leukemia. We herein report the case of a patient who underwent successful fertility treatment with frozen embryo preservation at 36 years of age, followed by embryo transfer at 39 years of age, thus resulting in pregnancy and delivery after a third discontinuation of tyrosine kinase inhibitors (TKIs). Despite the difficulty of long-term TKI withdrawal, the patient's strong desire for a baby led to a successful pregnancy and delivery with no apparent deformities or abnormalities. Thus, our case highlights the importance of collaboration between reproductive medicine physicians and hematologists.

摘要

辅助生殖技术是慢性髓性白血病孕妇可行的选择。我们在此报告了一例患者,她在 36 岁时通过冷冻胚胎保存成功进行了生育治疗,然后在 39 岁时进行了胚胎移植,从而在第三次停止酪氨酸激酶抑制剂(TKI)治疗后怀孕并分娩。尽管长期 TKI 停药困难,但患者强烈希望生育,最终成功怀孕并分娩,婴儿无明显畸形或异常。因此,我们的病例强调了生殖医学医生和血液科医生之间合作的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef90/11671195/0fd875e97d72/1349-7235-63-3233-g001.jpg

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