Vervier Jeanne, Guissard Françoise, Henket Monique, Calmes Doriane, Wirth Claudine, Louis Renaud, Schleich Florence
Clinique de l'Asthme, Service de Pneumologie, CHU Liège, Belgique.
Centre Hospitalier du Luxembourg, CHL Luxembourg.
Rev Med Liege. 2024 Apr;79(4):241-247.
The use of biotherapies has revolutionized the management of severe asthma. Following a review of asthma pathophysiology, which underpins the development of these new molecules, this article discusses the different types of remission in childhood and adult asthma. The possibilities of achieving remission with each biotherapy and the factors that predict remission will then be developed. Finally, we'll discuss the chances of maintaining good control of the disease after discontinuation of biotherapies, as well as their contribution in terms of systemic and local cortisone sparing.
生物疗法的应用彻底改变了重度哮喘的管理方式。在回顾了作为这些新分子研发基础的哮喘病理生理学之后,本文讨论了儿童和成人哮喘的不同缓解类型。接着将阐述每种生物疗法实现缓解的可能性以及预测缓解的因素。最后,我们将讨论停用生物疗法后维持疾病良好控制的机会,以及它们在减少全身和局部皮质激素使用方面的作用。