Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Metab Syndr Relat Disord. 2024 Aug;22(6):447-453. doi: 10.1089/met.2024.0009. Epub 2024 Apr 11.
This study evaluates insulin resistance prevalence in young females without diabetes, assessing risk factors and adiposity indices for early detection of cardiometabolic disorders. A cross-sectional study was conducted, involving 282 females aged 18-35 years from suburban and rural areas of Sri Lanka. Anthropometric measurements [height, weight, waist circumference (WC)] were obtained and biochemical parameters [fasting glucose, insulin, insulin resistance (IR), total cholesterol, high-density lipoproteins, (HDL), low-density lipoproteins, triglycerides] were measured. The anthropometric and biochemical data were compared between the groups of normal weight controls and overweight/obese cases, as well as between females with or without IR. The prevalence of IR in controls and cases were 48.6% and 57.1%, respectively. Both groups had mean Homeostasis Model Assessment-IR values greater than the normal cutoff value of 2.5. Females with IR showed higher prevalence of dyslipidemia than those without IR. Compared to the controls (2.81%), the prevalence of metabolic syndrome (MetS) was substantially greater among cases (46.42%). Both groups showed a statistically significant association between IR and MetS, but the association was considerably stronger in cases [ = 0.616, odds ratio (OR) >8] than in controls ( = 0.175, OR >1). Controls exhibited lower HDL levels, hypertriglyceridemia, and elevated IR levels ( < 0.05), and their ORs for acquiring MetS were >2, <1, and >3, respectively. Importantly, overweight/obese cases exhibited a significant association ( < 0.05) with all the MetS risk variables. Visceral adiposity index (VAI) proves to be a precise measurement for identifying IR and cardiovascular disease (CVD) among young females ( = -3.651), surpassing the accuracy of other indices. Body mass index, body round index, a body shape index, and WC were also reliable measurements to assess IR and the risk of CVD ( < 0.05). The study underscores the importance of assessing IR in nondiabetic young females to identify early cardiometabolic risks. VAI emerges as a precise measurement for identifying IR and CVD risk, surpassing the accuracy of other indices.
本研究评估了无糖尿病的年轻女性中胰岛素抵抗的患病率，评估了早期发现心血管代谢紊乱的危险因素和肥胖指数。这是一项横断面研究，共纳入了来自斯里兰卡郊区和农村地区的 282 名 18-35 岁的女性。测量了人体测量学指标（身高、体重、腰围[WC]）和生化参数（空腹血糖、胰岛素、胰岛素抵抗[IR]、总胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯）。比较了体重正常对照组和超重/肥胖组以及有或无 IR 的女性之间的人体测量学和生化数据。对照组和病例组的 IR 患病率分别为 48.6%和 57.1%。两组的稳态模型评估-IR 值均高于 2.5 的正常截断值。与无 IR 的女性相比，有 IR 的女性血脂异常的患病率更高。与对照组（2.81%）相比，病例组的代谢综合征（MetS）患病率显著更高（46.42%）。两组之间均存在 IR 与 MetS 之间的统计学显著关联，但病例组的关联强度更大（ = 0.616，优势比（OR）>8），对照组的关联强度较小（ = 0.175，OR>1）。对照组的高密度脂蛋白水平较低、高甘油三酯血症和高胰岛素抵抗水平（ < 0.05），并且获得 MetS 的 OR 分别大于 2、小于 1 和大于 3。重要的是，超重/肥胖病例与所有 MetS 风险变量均存在显著关联（ < 0.05）。内脏脂肪指数（VAI）证明是一种精确的测量方法，可以识别年轻女性中的 IR 和心血管疾病（CVD）（ = -3.651），其准确性超过其他指数。体重指数、体圆指数、体形成指数和 WC 也是评估 IR 和 CVD 风险的可靠测量方法（ < 0.05）。本研究强调了在非糖尿病年轻女性中评估 IR 的重要性，以识别早期的心血管代谢风险。VAI 是一种精确的测量方法，可用于识别 IR 和 CVD 风险，其准确性超过其他指数。
