INMED, INSERM, Aix-Marseille University, Marseille, France.
Neurosci Biobehav Rev. 2024 Jun;161:105671. doi: 10.1016/j.neubiorev.2024.105671. Epub 2024 Apr 9.
The mouse visual system has become the most popular model to study the cellular and circuit mechanisms of sensory processing. However, the importance of eye movements only started to be appreciated recently. Eye movements provide a basis for predictive sensing and deliver insights into various brain functions and dysfunctions. A plethora of knowledge on the central control of eye movements and their role in perception and behaviour arose from work on primates. However, an overview of various eye movements in mice and a comparison to primates is missing. Here, we review the eye movement types described to date in mice and compare them to those observed in primates. We discuss the central neuronal mechanisms for their generation and control. Furthermore, we review the mounting literature on eye movements in mice during head-fixed and freely moving behaviours. Finally, we highlight gaps in our understanding and suggest future directions for research.
小鼠视觉系统已成为研究感觉处理的细胞和回路机制的最流行模型。然而，眼球运动的重要性直到最近才开始被认识到。眼球运动为预测传感提供了基础，并深入了解了各种大脑功能和功能障碍。大量关于眼球运动的中枢控制及其在感知和行为中的作用的知识来自于灵长类动物的研究。然而，目前还缺乏对小鼠各种眼球运动的概述以及与灵长类动物的比较。在这里，我们回顾了迄今为止在小鼠中描述的眼球运动类型，并将其与灵长类动物观察到的运动类型进行了比较。我们讨论了它们产生和控制的中枢神经元机制。此外，我们还回顾了在头部固定和自由运动行为期间小鼠眼球运动的大量文献。最后，我们强调了我们理解中的差距，并为未来的研究提出了建议。
