肺移植活体供者的术后并发症
Postoperative Complications in Living Donors for Lung Transplantation.
作者信息
Tanaka Shin, Fujii Kento, Ishihara Megumi, Choshi Haruki, Matsubara Kei, Hashimoto Kohei, Okahara Shuji, Shien Kazuhiko, Suzawa Ken, Miyoshi Kentaroh, Yamamoto Hiromasa, Okazaki Mikio, Sugimoto Seiichiro, Toyooka Shinichi
机构信息
Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital, Okayama, Japan.
出版信息
Transplant Direct. 2024 Apr 9;10(5):e1617. doi: 10.1097/TXD.0000000000001617. eCollection 2024 May.
BACKGROUND
Living donor lobar lung transplantation is a life-saving procedure for critically ill patients. This requires 2 healthy donors exposed to risks and without medical benefit. Therefore, the donor's safety and minimal postoperative complications are crucial. This study aimed to investigate the short-term outcomes and identify the risk factors affecting these outcomes.
METHODS
The data of 175 living donors enrolled between 1998 and 2022 were analyzed. Donors were divided into era 1 (1998-2009) and era 2 (2010-2022).
RESULTS
The overall incidence of postoperative complications was 39%, of which 7% were major complications. Donors who underwent surgery on the right side had a higher incidence of delayed pulmonary fistulae ( = 0.01) and elevated liver enzyme levels ( = 0.028). Living donor surgery on the right side ( = 0.01), era 2 ( = 0.01), and the need for plasty ( = 0.04) were predictors of postoperative complications.
CONCLUSIONS
Updated data on complications and their correlation with postoperative quality of life from this study could aid in the selection of potential donors and facilitate informed consent.
背景
活体供体肺叶移植是挽救重症患者生命的手术。这需要2名健康供体承担风险且无医疗益处。因此，供体的安全性和术后并发症最少至关重要。本研究旨在调查短期结局并确定影响这些结局的风险因素。
方法
分析了1998年至2022年期间登记的175名活体供体的数据。供体分为第1阶段（1998 - 2009年）和第2阶段（2010 - 2022年）。
结果
术后并发症的总体发生率为39%，其中7%为严重并发症。接受右侧手术的供体延迟性肺瘘发生率较高（=0.01），肝酶水平升高（=0.028）。右侧活体供体手术（=0.01）、第2阶段（=0.01）以及需要整形（=0.04）是术后并发症的预测因素。
结论
本研究中关于并发症及其与术后生活质量相关性的最新数据有助于选择潜在供体并促进知情同意。
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