雄性生殖细胞中的表观遗传启动。
Epigenetic priming in the male germline.
机构信息
Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616, USA.
Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616, USA.
出版信息
Curr Opin Genet Dev. 2024 Jun;86:102190. doi: 10.1016/j.gde.2024.102190. Epub 2024 Apr 11.
Epigenetic priming presets chromatin states that allow the rapid induction of gene expression programs in response to differentiation cues. In the germline, it provides the blueprint for sexually dimorphic unidirectional differentiation. In this review, we focus on epigenetic priming in the mammalian male germline and discuss how cellular memories are regulated and inherited to the next generation. During spermatogenesis, epigenetic priming predetermines cellular memories that ensure the lifelong maintenance of spermatogonial stem cells and their subsequent commitment to meiosis and to the production of haploid sperm. The paternal chromatin state is also essential for the recovery of totipotency after fertilization and contributes to paternal epigenetic inheritance. Thus, epigenetic priming establishes stable but reversible chromatin states during spermatogenesis and enables epigenetic inheritance and reprogramming in the next generation.
表观遗传引发预先设定染色质状态，使基因表达程序能够快速响应分化信号。在生殖细胞中，它为有性二型的单向分化提供蓝图。在这篇综述中，我们专注于哺乳动物雄性生殖细胞中的表观遗传引发，并讨论细胞记忆是如何被调控和遗传到下一代的。在精子发生过程中，表观遗传引发预先设定了细胞记忆，确保精原干细胞的终身维持，以及它们随后向减数分裂和产生单倍体精子的分化。父本染色质状态对于受精后的全能性恢复也是必不可少的，并有助于父本的表观遗传遗传。因此，表观遗传引发在精子发生过程中建立了稳定但可逆转的染色质状态，并使下一代的表观遗传遗传和重编程成为可能。
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