硫氰酸盐和次硫氰酸对肺部感染的治疗潜力。
The therapeutic potential of thiocyanate and hypothiocyanous acid against pulmonary infections.
机构信息
Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Pediatrics, Division of Pulmonary, Allergy & Immunology, Cystic Fibrosis, and Sleep Medicine, Emory University, Atlanta, GA, USA.
出版信息
Free Radic Biol Med. 2024 Jul;219:104-111. doi: 10.1016/j.freeradbiomed.2024.04.217. Epub 2024 Apr 11.
Hypothiocyanous acid (HOSCN) is an endogenous oxidant produced by peroxidase oxidation of thiocyanate (SCN), an ubiquitous sulfur-containing pseudohalide synthesized from cyanide. HOSCN serves as a potent microbicidal agent against pathogenic bacteria, viruses, and fungi, functioning through thiol-targeting mechanisms, independent of currently approved antimicrobials. Additionally, SCN reacts with hypochlorous acid (HOCl), a highly reactive oxidant produced by myeloperoxidase (MPO) at sites of inflammation, also producing HOSCN. This imparts both antioxidant and antimicrobial potential to SCN. In this review, we discuss roles of HOSCN/SCN in immunity and potential therapeutic implications for combating infections.
次碘酸氢盐（HOSCN）是一种内源性氧化剂，由过氧化物酶氧化硫氰酸盐（SCN）产生，SCN 是一种普遍存在的含硫假卤化物，由氰化物合成。HOSCN 作为一种有效的杀菌剂，能够对抗致病菌、病毒和真菌，其作用机制是通过靶向巯基的方式发挥作用，与目前批准的抗生素无关。此外，SCN 与次氯酸（HOCl）反应，HOCl 是一种由髓过氧化物酶（MPO）在炎症部位产生的高反应性氧化剂，也会产生 HOSCN。这赋予了 SCN 抗氧化和抗菌的潜力。在这篇综述中，我们讨论了 HOSCN/SCN 在免疫中的作用及其在抗感染治疗方面的潜在应用。
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