长链非编码RNA RMST通过miR-204-5p与胃癌的进展和预后相关。
lncRNA RMST is associated with the progression and prognosis of gastric cancer via miR-204-5p.
作者信息
Cai Huimei, Li Chenhui, Wu Zhou
机构信息
Department of Gastroenterology, Affiliated Fuzhou First Hospital of Fujian Medical University, No. 190, Dadao Road, Taijiang District, Fuzhou, 350000, China.
Department of Clinical Medicine, Fujian Medical University, Fuzhou, 350122, China.
出版信息
Cell Div. 2024 Apr 12;19(1):12. doi: 10.1186/s13008-024-00117-x.
BACKGROUND
Exploring novel biomarkers for gastric cancer holds promise for enhancing patients' therapy and survival rates. lncRNAs and miRNAs have emerged as important biomarkers for various human cancers. However, the role of lncRNA RMST (RMST) in gastric cancer development and the mechanism underlying its function remains unclear.
RESULTS
Significant upregulation of RMST was observed in gastric cancer tumor tissues. RMST levels showed strong correlation with patients' lymph node metastasis and TNM stage and serving as a predictor of adverse prognosis RMST negatively regulated miR-204-5p, which in turn mediated the inhibitory effects of RMST knockdown on gastric cancer cell growth and metastasis.
CONCLUSION
RMST served as both a prognostic biomarker and tumor promoter by modulating miR-204-5p. Inhibiting RMST could represent a novel and potential therapeutic strategy for gastric cancer.
背景
探索胃癌的新型生物标志物有望提高患者的治疗效果和生存率。长链非编码RNA（lncRNA）和微小RNA（miRNA）已成为多种人类癌症的重要生物标志物。然而，lncRNA RMST在胃癌发生发展中的作用及其功能机制仍不清楚。
结果
在胃癌肿瘤组织中观察到RMST显著上调。RMST水平与患者的淋巴结转移和TNM分期密切相关，可作为不良预后的预测指标。RMST负向调节miR-204-5p，进而介导RMST敲低对胃癌细胞生长和转移的抑制作用。
结论
RMST通过调节miR-204-5p发挥预后生物标志物和肿瘤促进因子的作用。抑制RMST可能是一种新型的潜在胃癌治疗策略。
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