爱尔兰的疫苗诱导血栓形成和血小板减少症（VITT）：病例及当前做法综述
Vaccine-induced thrombosis and thrombocytopenia (VITT) in Ireland: A review of cases and current practices.
作者信息
Swan D, Enright H, Desmond R, Le G, El Hassadi E, Hennessy B, Lynott F, O'Keeffe D, Crowley M, Smyth L, Perera K, Jennings C, Ni Ainle F, Coll J, Ryan K, O'Donnell J, Lavin M, O'Connell N
机构信息
National Coagulation Centre, St James' Hospital, Dublin, Ireland.
Tallaght University Hospital, Dublin, Ireland.
出版信息
Thromb Update. 2021 Dec;5:100086. doi: 10.1016/j.tru.2021.100086. Epub 2021 Nov 10.
Since the beginning of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) virus pandemic, several highly effective and safe vaccines have been produced at remarkable speed. Following global implementation of vaccination programmes, cases of thrombosis with thrombocytopenia following administration of adenoviral vector-based vaccines started being reported. In this review we discuss the known pathogenesis and epidemiology of so-called vaccine induced thrombocytopenia and thrombosis (VITT). We consider the available guidelines, diagnostic laboratory tests and management options for these patients. Finally, we discuss important unanswered questions and areas for future research in this novel pathoclinical entity.
自严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行开始以来，已以惊人的速度生产了几种高效且安全的疫苗。在全球实施疫苗接种计划后，开始有报告称接种腺病毒载体疫苗后出现血栓形成伴血小板减少的病例。在本综述中，我们讨论了所谓的疫苗诱导的血小板减少和血栓形成（VITT）的已知发病机制和流行病学。我们考虑了针对这些患者的现有指南、诊断实验室检查和管理选项。最后，我们讨论了这个新的病理临床实体中重要的未解决问题和未来研究领域。
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