Department of Diagnostic Pathology, Shandong Second Medical University, Weifang, 261053, China.
Department of Ultrasound, Weifang People's Hospital, Weifang, 261041, China.
Med Oncol. 2024 Apr 17;41(5):119. doi: 10.1007/s12032-024-02343-3.
Chromatin remodeling is a critical step in the DNA damage response, and the ATP-dependent chromatin remodelers are a group of epigenetic regulators that alter nucleosome assembly and regulate transcription factor accessibility to DNA, preventing genomic instability and tumorigenesis caused by DNA damage. The SWI/SNF chromatin remodeling complex is one of them, and mutations in the gene encoding the SWI/SNF subunit are frequently found in digestive tumors. We review the most recent literature on the role of SWI/SNF complexes in digestive tumorigenesis, with different SWI/SNF subunits playing different roles. They regulate the biological behavior of tumor cells, participate in multiple signaling pathways, interact with multiple genes, and have some correlation with the prognosis of patients. Their carcinogenic properties may help discover new therapeutic targets. Understanding the mutations and defects of SWI/SNF complexes, as well as the underlying functional mechanisms, may lead to new strategies for treating the digestive system by targeting relevant genes or modulating the tumor microenvironment.
染色质重塑是 DNA 损伤反应的关键步骤，而依赖于 ATP 的染色质重塑因子是一组表观遗传调节剂，它们可以改变核小体的组装并调节转录因子对 DNA 的可及性，从而防止由 DNA 损伤引起的基因组不稳定性和肿瘤发生。SWI/SNF 染色质重塑复合物就是其中之一，编码 SWI/SNF 亚基的基因突变在消化道肿瘤中经常被发现。我们回顾了关于 SWI/SNF 复合物在消化道肿瘤发生中的作用的最新文献，不同的 SWI/SNF 亚基发挥着不同的作用。它们调节肿瘤细胞的生物学行为，参与多种信号通路，与多个基因相互作用，并与患者的预后有一定的相关性。它们的致癌特性可能有助于发现新的治疗靶点。了解 SWI/SNF 复合物的突变和缺陷，以及潜在的功能机制，可能会通过针对相关基因或调节肿瘤微环境，为治疗消化系统提供新的策略。
