Bianchi A T, Hussaarts-Odijk L M, Benner R
Immunobiology. 1985 Sep;170(3):192-202. doi: 10.1016/S0171-2985(85)80091-7.
Secondary type delayed type hypersensitivity (DTH) in mice against class I alloantigens or non-H-2 alloantigens is characterized by an earlier appearance of DTH reactivity after booster immunization compared with the development of DTH reactivity after primary immunization. In contrast to the primary and secondary DTH against class I or non-H-2 alloantigens, the development of secondary DTH against class II alloantigens or a set of alloantigens that includes class II alloantigens is not faster than the development of primary DTH. Thus, primary and secondary immunization with class II alloantigens prevents secondary type DTH reactivity to simultaneously administered class I alloantigens and non-H-2 alloantigens.
小鼠针对I类同种异体抗原或非H-2同种异体抗原的继发性迟发型超敏反应（DTH）的特征是，与初次免疫后DTH反应的发展相比，加强免疫后DTH反应出现得更早。与针对I类或非H-2同种异体抗原的初次和继发性DTH不同，针对II类同种异体抗原或一组包括II类同种异体抗原的同种异体抗原的继发性DTH的发展并不比初次DTH的发展更快。因此，用II类同种异体抗原进行初次和二次免疫可预防对同时给予的I类同种异体抗原和非H-2同种异体抗原的继发性DTH反应。
