Postgraduate Program in Health Sciences, PUC-Campinas, SP, Brazil.
Wisconsin Institutes for Medical Research, WIMR II, Department of Neurology (SMPH), University of Wisconsin, Madison, USA.
CNS Neurol Disord Drug Targets. 2024;23(12):1401-1404. doi: 10.2174/0118715273279600240403040324.
The literature has shown the relevance of nutritional and metabolic aspects in patients with epilepsy. This study evaluated the relationship between clinical variables and plasma proteins and compared the variables between seizure frequency and neurological examination. A pilot study was carried out with eighty-four (n = 84) adults patients with epilepsy. The relationship between clinical variables of the disease (age at disease onset, neurological examination, current type and frequency of seizures, duration of disease, amount of antiseizure medications-ASM used and type and etiology of epilepsy) and plasma proteins (albumin and transferrin) was investigated. In the statistical analysis, the chi-square, Fisher, Mann-Whitney, Kruskal-Wallis tests, Spearman coefficient and univariate logistic regression were used. There was a significant association between the use of antiseizure medications (ASM) (p = 0.0105) and altered neurological examination (p = 0.0049), compared with the frequency of seizures, and between albumin and gender (p = 0.0005), and albumin and etiology of epilepsy (p = 0.0186). There was a significant low-intensity and inverse linear correlation (coefficient = -0.31363, p = 0.0037) between albumin and disease duration. In the logistic regression model, a significant association was only observed between the number of ASM and the frequency of seizures (p = 0.0120; OR = 3.368; 95% CI = 1.305-8.691). There was no association between plasma proteins and the outcomes of seizure frequency and neurological examination. The number of ASM and not protein metabolism was associated with frequency of seizures in patients with epilepsy.
文献表明，营养和代谢方面与癫痫患者密切相关。本研究评估了临床变量与血浆蛋白之间的关系，并比较了发作频率和神经系统检查之间的变量。对 84 名癫痫成年患者进行了一项初步研究。研究了疾病的临床变量（发病年龄、神经系统检查、当前发作类型和频率、疾病持续时间、抗癫痫药物（ASM）的用量以及癫痫的类型和病因）与血浆蛋白（白蛋白和转铁蛋白）之间的关系。在统计分析中，使用了卡方检验、Fisher 检验、Mann-Whitney 检验、Kruskal-Wallis 检验、Spearman 系数和单变量逻辑回归。与发作频率相比，ASM 的使用（p = 0.0105）和改变的神经系统检查（p = 0.0049）与抗癫痫药物的使用显著相关，白蛋白与性别（p = 0.0005）和癫痫的病因（p = 0.0186）显著相关。白蛋白与疾病持续时间之间存在显著的低强度和反向线性相关性（系数=-0.31363，p=0.0037）。在逻辑回归模型中，仅观察到 ASM 的数量与发作频率之间存在显著相关性（p=0.0120；OR=3.368；95%CI=1.305-8.691）。血浆蛋白与发作频率和神经系统检查结果之间没有相关性。在癫痫患者中，与发作频率相关的是 ASM 的数量，而不是蛋白质代谢。
