Division of Pediatric Respiratory and Sleep Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
School of Medicine, The University of Jordan, Amman, Jordan.
J Neonatal Perinatal Med. 2024;17(2):261-264. doi: 10.3233/NPM-230163.
Cyanosis is a bluish discoloration of the tissues due to increased levels of deoxygenated hemoglobin in capillaries. It is a common finding in newborn infants that can be caused by different diseases, including pulmonary, cardiac, infectious, and hematological disorders. Methemoglobinemia is a rare cause of cyanosis, in which hemoglobin is oxidized, changing its heme iron configuration from the ferrous (Fe2 +) to the ferric (Fe3 +) state, creating methemoglobin (Met-Hb), a form that does not bind oxygen, leading to decreased oxygen delivery to the tissues and cyanosis. We report a rare case of a preterm newborn, who developed cyanosis and worsening hypoxemia on day ten of life, she was found to have elevated Met-Hb percentage in blood gas analysis that required treatment with intravenous methylene blue. Her symptoms resolved after a period of maintenance treatment with oral methylene blue and ascorbic acid, and the etiology of her disease remains unclear.
发绀是由于毛细血管中脱氧血红蛋白水平升高导致的组织变蓝。这是新生儿的常见现象，可能由不同的疾病引起，包括肺部、心脏、感染和血液疾病。高铁血红蛋白血症是发绀的罕见原因，其中血红蛋白被氧化，使其血红素铁的构型从亚铁（Fe2+）变为高铁（Fe3+）状态，形成高铁血红蛋白（Met-Hb），这种形式不能结合氧气，导致向组织输送的氧气减少并出现发绀。我们报告了一例罕见的早产儿病例，她在出生后第 10 天出现发绀和缺氧恶化，血液气体分析发现高铁血红蛋白百分比升高，需要静脉注射亚甲蓝治疗。她的症状在一段时间的亚甲蓝和抗坏血酸维持治疗后得到缓解，她的疾病病因仍不清楚。
