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基孔肯雅热中的细胞因子风暴:我们能否称之为与基孔肯雅热相关的多系统炎症综合征?

Cytokine storm in Chikungunya: Can we call it multisystem inflammatory syndrome associated with Chikungunya?

机构信息

Pediatric Rheumatology, Pediatrics Department, Hospital Central del Instituto de Previsión Social, Universidad Católica de Asunción, Paraguay.

Pediatric Intensive Care, Pediatrics Department, Hospital Central del Instituto de Previsión Social, Universidad Católica de Asunción, Paraguay.

出版信息

Reumatol Clin (Engl Ed). 2024 Apr;20(4):223-225. doi: 10.1016/j.reumae.2024.04.005.


DOI:10.1016/j.reumae.2024.04.005
PMID:38644032
Abstract

Paraguay is currently facing a new outbreak of Chikungunya virus. This report summarizes two severe cases of Chikungunya (CHIKV) infection, confirmed by real-time reverse transcription polymerase chain reaction. We present the cases of patients with acute CHIKV infection and multisystem involvement, with fever, rash, abdominal pain, vomiting, myocarditis, and coronary artery anomalies, very similar to the cases described in MIS-C related to SARS-CoV-2 during the COVID-19 Pandemic. Both patients received IVIG and methylprednisolone, with good clinical response. In this setting of cytokine storm in Chikungunya, can we call it "Multisystem inflammatory syndrome associated with Chikungunya"?.

摘要

巴拉圭目前正面临着基孔肯雅热病毒的新疫情爆发。本报告总结了两例通过实时逆转录聚合酶链反应确诊的严重基孔肯雅热(CHIKV)感染病例。我们报告了两例急性 CHIKV 感染和多系统受累的患者病例,表现为发热、皮疹、腹痛、呕吐、心肌炎和冠状动脉异常,与 COVID-19 大流行期间与 SARS-CoV-2 相关的 MIS-C 病例非常相似。两名患者均接受了静脉注射免疫球蛋白和甲基强的松龙治疗,临床反应良好。在这种基孔肯雅热细胞因子风暴的情况下,我们能否称之为“与基孔肯雅热相关的多系统炎症综合征”?

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[1]
Cytokine storm in Chikungunya: Can we call it multisystem inflammatory syndrome associated with Chikungunya?

Reumatol Clin (Engl Ed). 2024-4

[2]
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Am J Case Rep. 2021-9-12

[3]
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[4]
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[5]
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[6]
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引用本文的文献

[1]
Assessing the potential impact of salidroside on Chikungunya virus-induced acute interstitial nephritis via network pharmacology, molecular docking and experiments.

Front Cell Infect Microbiol. 2025-7-22

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