Tanaka Mitsuki, Hatayama Yoshiomi, Kawaguchi Hideo, Fujioka Ichitaro, Aoki Masahiro
Department of Radiation Oncology, Hirosaki University Graduate School of Medicine, Hirosaki, JPN.
Cureus. 2024 Mar 22;16(3):e56689. doi: 10.7759/cureus.56689. eCollection 2024 Mar.
Anaplastic thyroid carcinoma, a rare type of primary thyroid cancer, is one of the most aggressive neoplasms with a poor prognosis. Many cases are in the advanced stage at the time of the initial visit, and curative treatment is impossible. Because of the highly radioresistant nature of anaplastic thyroid carcinoma, this condition cannot be properly controlled with conventional radiotherapy. Herein, we report the case of a patient with anaplastic thyroid carcinoma who underwent hypofractionated radiotherapy, attained a complete response, and is still alive more than 10 years after treatment with no evidence of disease. To overcome the high radioresistance of anaplastic thyroid carcinoma, we administered 50 Gy in 10 fractions three times a week. Furthermore, we administered paclitaxel and carboplatin sequentially before and after radiotherapy. Consequently, the patient completed treatment and reached a complete response. He is still alive more than 10 years after treatment with no evidence of disease or severe adverse events. Hypofractionated radiation therapy may provide good control of locally advanced anaplastic thyroid carcinoma.
间变性甲状腺癌是一种罕见的原发性甲状腺癌，是最具侵袭性的肿瘤之一，预后较差。许多病例在初诊时就已处于晚期，无法进行根治性治疗。由于间变性甲状腺癌具有高度放射抗性，传统放疗无法有效控制这种疾病。在此，我们报告一例间变性甲状腺癌患者，该患者接受了大分割放疗，获得了完全缓解，并且在治疗后存活超过10年，无疾病迹象。为克服间变性甲状腺癌的高放射抗性，我们每周三次，分10次给予50 Gy的剂量。此外，我们在放疗前后序贯给予紫杉醇和卡铂。结果，患者完成治疗并达到完全缓解。治疗后他存活超过10年，无疾病迹象或严重不良事件。大分割放射治疗可能对局部晚期间变性甲状腺癌有良好的控制效果。
