The objectives of this symposium review are to summarize relevant research and key welfare issues relative to calf transportation and identify strategies to mitigate welfare challenges. An important animal welfare concern across the US dairy industry is the transportation of preweaning calves from the source dairy to a calf-raising facility (e.g., calf ranches, heifer raising facilities, veal operations), auction, livestock market, or directly to slaughter. Millions of calves are transported annually in the United States and calf transport has garnered increased attention. Transportation stressors include limited (if any) access to food and water, commingling, environmental temperature changes, and a variety of handling techniques. Calves in the United States are often transported at an average age of 3 d, and in many cases, less than 24 h of age. Neonates are particularly vulnerable to transportation stressors due to their decreased ability to thermoregulate, underdeveloped immune system, and immature physiologic stress responses. In addition to age, fitness for transport is a key welfare consideration; recent data from the United States demonstrate that some source dairies transport compromised calves (i.e., dehydration, diarrhea, navel inflammation, and so on), leading to important welfare challenges during transportation. Calves arriving at US veal facilities have been reported to be dehydrated, lethargic, hypoglycemic, and may also have poor body condition, navel inflammation, and diarrhea. Thus, there is ample opportunity to target decision-making and producer-focused education not only at the source dairy, but also at each stage of transportation to address critical welfare concerns. In addition, the supply chain and procurement model that influence calf transport practices should be evaluated to determine potential opportunities to improve calf welfare. Here, we provide 5 potential strategies to improve the welfare of transported calves: (1) provide excellent newborn care that "preconditions" calves for transport, (2) assess calves' fitness-for-transport to ensure they can withstand the journey, (3) handle calves with care, (4) wait until calves are older to transport, and (5) reduce transport duration.