Tretiakov Peter S, Onafowokan Oluwatobi O, Mir Jamshaid M, Lorentz Nathan, Galetta Matthew, Das Ankita, Shin John, Sciubba Daniel, Krol Oscar, Joujon-Roche Rachel, Williamson Tyler, Imbo Bailey, Yee Timothy, Jankowski Pawel P, Hockley Aaron, Schoenfeld Andrew J, Passias Peter G
Departments of Orthopedic and Neurological Surgery, NYU Langone Orthopedic Hospital; New York Spine Institute, New York, NY, USA.
Department of Neurosurgery, Massachusetts General Hospitals, Boston MA, USA.
Global Spine J. 2025 Apr;15(3):1544-1551. doi: 10.1177/21925682241249105. Epub 2024 Apr 22.
Study DesignRetrospective cohort study.ObjectivesTo assess the impact of Enhanced recovery after surgery (ERAS) protocols on peri-operative course in adult cervical deformity (ACD) corrective surgery.MethodsPatients ≥18 yrs with complete pre-(BL) and up to 2-year (2Y) radiographic and clinical outcome data were stratified by enrollment in an ERAS protocol that commenced in 2020. Differences in demographics, clinical outcomes, radiographic alignment targets, peri-operative factors and complication rates were assessed via means comparison analysis. Logistic regression analysed differences while controlling for baseline disability and deformity.ResultsWe included 220 patients (average age 58.1 ± 11.9 years, 48% female). 20% were treated using the ERAS protocol (ERAS+). Disability was similar between both groups at baseline. When controlling for baseline disability and myelopathy, ERAS- patients were more likely to utilize opioids than ERAS+ (OR 1.79, 95% CI: 1.45-2.50, = .016). Peri-operatively, ERAS+ had significantly lower operative time ( < .021), lower EBL (583.48 vs 246.51, < .001), and required significantly lower doses of propofol intra-operatively than ERAS- patients ( = .020). ERAS+ patients also reported lower mean LOS overall (4.33 vs 5.84, = .393), and were more likely to be discharged directly to home (χ2(1) = 4.974, = .028). ERAS+ patients were less likely to require steroids after surgery ( = .045), were less likely to develop neuromuscular complications overall ( = .025), and less likely experience venous complications or be diagnosed with venous disease post-operatively ( = .025).ConclusionsEnhanced recovery after surgery programs in ACD surgery demonstrate significant benefit in terms of peri-operative outcomes for patients.
研究设计
回顾性队列研究。
目的
评估成人颈椎畸形(ACD)矫正手术中术后加速康复(ERAS)方案对围手术期过程的影响。
方法
纳入年龄≥18岁且术前(基线)资料完整、有长达2年影像学和临床结局数据的患者,根据是否纳入2020年开始实施的ERAS方案进行分层。通过均值比较分析评估人口统计学、临床结局、影像学对线目标、围手术期因素和并发症发生率的差异。采用逻辑回归分析差异,并对基线残疾和畸形情况进行控制。
结果
我们纳入了220例患者(平均年龄58.1±11.9岁,48%为女性)。20%的患者采用ERAS方案治疗(ERAS+组)。两组患者基线时的残疾情况相似。在控制基线残疾和脊髓病后,非ERAS组患者比ERAS+组更有可能使用阿片类药物(比值比1.79,95%置信区间:1.45 - 2.50,P = 0.016)。在围手术期,ERAS+组的手术时间显著更短(P < 0.021),估计失血量更低(583.48对246.51,P < 0.001),术中丙泊酚用量显著低于非ERAS组患者(P = 0.020)。ERAS+组患者总体住院时间也更短(4.33对5.84,P = 0.393),且更有可能直接出院回家(χ2(1)=4.974,P = 0.028)。ERAS+组患者术后使用类固醇的可能性较小(P = 0.045),总体发生神经肌肉并发症的可能性较小(P = 0.025),术后发生静脉并发症或被诊断为静脉疾病的可能性也较小(P = 0.025)。
结论
ACD手术中的术后加速康复方案在患者围手术期结局方面显示出显著益处。