Department of Pharmacy, Chongqing Traditional Chinese Medicine Hospital, 400021, Chongqing, P.R. China.
Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, No. 6 Panxi 7 Branch Road, 400021, Chongqing, P.R. China.
BMC Nephrol. 2024 Apr 22;25(1):140. doi: 10.1186/s12882-024-03570-6.
Contrast-induced acute kidney injury (CI-AKI) has become the third leading cause of hospital-acquired AKI, which seriously threatens the health of patients. To date, the precise pathogenesis of CI-AKI has remained not clear and may be related to the direct cytotoxicity, hypoxia and ischemia of medulla, and oxidative stress caused by iodine contrast medium, which have diverse physicochemical properties, including cytotoxicity, permeability and viscosity. The latest research shows that microRNAs (miRNAs) are also involved in apoptosis, pyroptosis, and autophagy which caused by iodine contrast medium (ICM), which may be implicated in the pathogenesis of CI-AKI. Unfortunately, effective therapy of CI-AKI is very limited at present. Therefore, effective prevention of CI-AKI is of great significance, and several preventive options, including hydration, antagonistic vasoconstriction, and antioxidant drugs, have been developed. Here, we review current knowledge about the features of iodine contrast medium, the definition, pathogenesis, molecular mechanism, risk factors, prevention and treatment of CI-AKI.
对比剂诱导的急性肾损伤（CI-AKI）已成为医院获得性 AKI 的第三大原因，严重威胁患者健康。迄今为止，CI-AKI 的精确发病机制仍不清楚，可能与碘对比剂的直接细胞毒性、髓质缺氧和缺血以及氧化应激有关，碘对比剂具有不同的物理化学特性，包括细胞毒性、通透性和粘度。最新研究表明，微小 RNA（miRNA）也参与了由碘对比剂（ICM）引起的细胞凋亡、焦亡和自噬，这可能与 CI-AKI 的发病机制有关。不幸的是，目前对 CI-AKI 的有效治疗方法非常有限。因此，CI-AKI 的有效预防具有重要意义，已经开发了几种预防方案，包括水化、拮抗血管收缩和抗氧化药物。在这里，我们综述了目前关于碘对比剂的特性、定义、发病机制、分子机制、危险因素、预防和治疗 CI-AKI 的知识。
