实体瘤中有效 CAR-T 细胞免疫疗法面临的挑战和策略。
Challenges and strategies in relation to effective CAR-T cell immunotherapy for solid tumors.
机构信息
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
出版信息
Med Oncol. 2024 Apr 23;41(5):126. doi: 10.1007/s12032-024-02310-y.
Chimeric Antigen Receptor T cell (CAR-T) therapy has revolutionized cancer treatment, but its application to solid tumors is limited. CAR-T cells have poor incapability of entering, surviving, proliferating, and finally exerting function in the tumor microenvironment. This review summarizes the main strategies related to enhancing the infiltration, efficacy, antigen recognition, and production of CAR-T in solid tumors. Additional applications of CAR-γδ T and macrophages are also discussed. We believe CAR-T will be a milestone in treating solid tumors once these problems are solved.
嵌合抗原受体 T 细胞（CAR-T）疗法已经彻底改变了癌症治疗，但它在实体瘤中的应用受到限制。CAR-T 细胞进入、存活、增殖和最终在肿瘤微环境中发挥功能的能力很差。本综述总结了增强 CAR-T 在实体瘤中浸润、疗效、抗原识别和产生的主要策略。还讨论了 CAR-γδ T 和巨噬细胞的其他应用。我们相信，一旦解决了这些问题，CAR-T 将成为治疗实体瘤的一个里程碑。
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