1例弥漫性大B细胞淋巴瘤合并失代偿期酒精性肝硬化经化疗免疫治疗成功治愈。
A case of diffuse large B-cell lymphoma with decompensated alcohol-related liver cirrhosis treated successfully by chemoimmunotherapy.
作者信息
Li Yan, Kong Ling-Zhijie
机构信息
Department of Haematology Hebei General Hospital Shijiazhuang Hebei People's Republic of China.
Department of Graduate School Hebei North University Zhangjiakou Hebei People's Republic of China.
出版信息
Clin Case Rep. 2024 Apr 23;12(4):e8820. doi: 10.1002/ccr3.8820. eCollection 2024 Apr.
KEY CLINICAL MESSAGE
This report describes a case of diffuse large B-cell lymphoma with MYD88 L265P and KM2DT mutation and decompensated alcohol-related liver cirrhosis. And the treatment is successful in this patient, who had multiple complications and poor prognostic factors.
ABSTRACT
This report describes a case of diffuse large B-cell lymphoma with MYD88 L265P and KM2DT mutation and decompensated alcohol-related liver cirrhosis. The lymphoma showed a complete response with no MYD88 L265P mutation after four courses of combination chemotherapy. Lymphoma is one of the most common malignant tumors, but cases of DLBCL with cirrhosis are much rarer especially with alcohol-related cirrhosis. And we reviewed the relevant mechanisms. Although we did not find a definite association between the pathogenesis of the patient's alcohol-related cirrhosis and that of diffuse large B-cell lymphoma, the treatment is successful in this patient, who had multiple complications and poor prognostic factors.
关键临床信息
本报告描述了一例伴有MYD88 L265P和KM2DT突变的弥漫性大B细胞淋巴瘤合并失代偿期酒精性肝硬化的病例。该患者有多种并发症且预后因素较差，但治疗取得了成功。
摘要
本报告描述了一例伴有MYD88 L265P和KM2DT突变的弥漫性大B细胞淋巴瘤合并失代偿期酒精性肝硬化的病例。经过四个疗程的联合化疗后，淋巴瘤完全缓解，且无MYD88 L265P突变。淋巴瘤是最常见的恶性肿瘤之一，但合并肝硬化的弥漫性大B细胞淋巴瘤病例更为罕见，尤其是合并酒精性肝硬化的情况。我们回顾了相关机制。虽然我们未发现该患者酒精性肝硬化的发病机制与弥漫性大B细胞淋巴瘤之间存在明确关联，但该患者有多种并发症且预后因素较差，治疗仍取得了成功。
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