Mollah Sha Abbas, Nayak Aditya, Barhai Swapna, Maity Uddip
Rajiv Gandhi University, Health Sciences Karnataka, East West College of Pharmacy, Department of Pharmacy Practice - Bengaluru Karnataka, India.
Dement Neuropsychol. 2024 Apr 22;18:e20230072. doi: 10.1590/1980-5764-DN-2023-0072. eCollection 2024.
Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder defined by the selective deterioration of the frontal and temporal lobes of the brain. This comprehensive review explored the effect of FTD on language, speech, and behavior. Early symptoms include difficulty in word finding, reduced speech output, and comprehension deficits, often leading to aphasia. The study discussed the profound behavioral changes observed in FTD patients, including apathy, disinhibition, compulsive behaviors, and loss of empathy, the importance of an accurate and early diagnosis, and its challenges. We even reviewed the potential for targeted therapies and the essential role of multidisciplinary care in managing the language, speech, and behavioral aspects of FTD. By examining objective data and comprehensive research on the subject, this study offers valuable insights into FTD's profound effects on language, speech, and behavior, assisting in improved clinical management and potential therapeutic strategies for this devastating condition.
额颞叶痴呆(FTD)是一种进行性神经退行性疾病,其定义为大脑额叶和颞叶的选择性退化。这篇综述探讨了FTD对语言、言语和行为的影响。早期症状包括找词困难、言语输出减少和理解缺陷,常导致失语症。该研究讨论了在FTD患者中观察到的深刻行为变化,包括冷漠、脱抑制、强迫行为和同理心丧失、准确早期诊断的重要性及其挑战。我们甚至回顾了靶向治疗的潜力以及多学科护理在管理FTD的语言、言语和行为方面的重要作用。通过检查关于该主题的客观数据和全面研究,本研究为FTD对语言、言语和行为的深远影响提供了有价值的见解,有助于改善对这种破坏性疾病的临床管理和潜在治疗策略。