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KIAA0040通过控制JAK2/STAT3信号通路促进胶质瘤生长。

KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway.

作者信息

He Jie, Xue Kaming, Fan Fei, Li Lin, Rao Xinyu, Liu Wei, Nie Chuansheng

机构信息

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Department of Traditional Chinese Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

出版信息

J Cell Mol Med. 2024 Apr;28(8):e18332. doi: 10.1111/jcmm.18332.

DOI:10.1111/jcmm.18332
PMID:38661644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11044867/
Abstract

The role of KIAA0040 role in glioma development is not yet understood despite its connection to nervous system diseases. In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumour cell death and promoting cell cycle advancement. Our findings suggest that targeting KIAA0040 could be an effective treatment for glioma due to its role in promoting aggressive tumour behaviour and poor prognosis.

摘要

尽管KIAA0040与神经系统疾病有关，但其在胶质瘤发展中的作用尚不清楚。在本研究中，使用qRT-PCR、WB和IHC评估了KIAA0040的表达水平，并进行了功能试验以评估其对胶质瘤进展的影响，同时进行了动物实验。此外，使用WB检测KIAA0040对JAK2/STAT3信号通路的影响。我们的研究发现，KIAA0040在胶质瘤中表达增加，与肿瘤分级和不良临床结果相关，是一个独立的预后因素。功能试验表明，KIAA0040通过激活JAK2/STAT3通路增强胶质瘤的生长、迁移和侵袭。当然，KIAA0040通过防止肿瘤细胞死亡和促进细胞周期进程来增强胶质瘤的生长。我们的研究结果表明，由于KIAA0040在促进肿瘤侵袭行为和不良预后方面的作用，靶向KIAA0040可能是治疗胶质瘤的有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/6097bdfed08d/JCMM-28-e18332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/281965b285ed/JCMM-28-e18332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/548e64fb9674/JCMM-28-e18332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/0a8ea85496d6/JCMM-28-e18332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/e2e3a000e20a/JCMM-28-e18332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/e5c972f4add0/JCMM-28-e18332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/6097bdfed08d/JCMM-28-e18332-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/281965b285ed/JCMM-28-e18332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/548e64fb9674/JCMM-28-e18332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/0a8ea85496d6/JCMM-28-e18332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/e2e3a000e20a/JCMM-28-e18332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/e5c972f4add0/JCMM-28-e18332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48ed/11044867/6097bdfed08d/JCMM-28-e18332-g004.jpg

相似文献

[1]
KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway.

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[2]
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[7]
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[10]
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引用本文的文献

[1]
Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway.

Sci Rep. 2025-2-4

[2]
RIT1 Promotes the Proliferation of Gliomas Through the Regulation of the PI3K/AKT/c-Myc Signalling Pathway.

J Cell Mol Med. 2025-1

本文引用的文献

[1]
PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer.

Cell Death Dis. 2023-10-9

[2]
Tumor-Associated Macrophage-Derived Exosomal LINC01232 Induces the Immune Escape in Glioma by Decreasing Surface MHC-I Expression.

Adv Sci (Weinh). 2023-6

[3]
A prognostic NAD+ metabolism-related gene signature for predicting response to immune checkpoint inhibitor in glioma.

Front Oncol. 2023-2-8

[4]
RNF7 promotes glioma growth via the PI3K/AKT signalling axis.

J Cell Mol Med. 2023-1

[5]
The WHO 2021 Classification of Central Nervous System tumours: a practical update on what neurosurgeons need to know-a minireview.

Acta Neurochir (Wien). 2022-9

[6]
STAT3 and p53: Dual Target for Cancer Therapy.

Biomedicines. 2020-12-21

[7]
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy.

Med Res Rev. 2020-12-1

[8]
Hypoxic Glioma Stem Cell-Derived Exosomes Containing Linc01060 Promote Progression of Glioma by Regulating the MZF1/c-Myc/HIF1α Axis.

Cancer Res. 2021-1-1

[9]
Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer.

Cells. 2020-9-29

[10]
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine.

Nat Commun. 2020-7-6

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