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撒哈拉以南非洲五岁以下儿童正常血红蛋白浓度的决定因素:一项采用横断面研究设计的正向偏差调查。

Determinants of normal haemoglobin concentration among under-five children in Sub-Saharan Africa: a Positive deviance inquiry using cross-sectional study design.

作者信息

Seifu Beminate Lemma, Tesema Getayeneh Antehunegn, Tebeje Tsion, Legesse Bruck Tesfaye, Yehuala Tirualem Zeleke, Wuneh Abel Gebre, Tadese Zinabu Bekele, Mare Kusse Urmale

机构信息

Department of Public Health, College of Medicine and Health Sciences, Samara University, Samara, Ethiopia

Epidemiology and Biostatistics, University of Gondar College of Medicine and Health Sciences, Gondar, Ethiopia.

出版信息

BMJ Open. 2024 Apr 24;14(4):e074477. doi: 10.1136/bmjopen-2023-074477.


DOI:10.1136/bmjopen-2023-074477
PMID:38663921
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11043768/
Abstract

BACKGROUND: Low haemoglobin level in children is linked with short-term and long-term consequences including developmental delay. Globally, over half of the children under the age of five years had low haemoglobin concentration. However, there is limited research on the prevalence and determinants of normal haemoglobin concentration among under-five children in sub-Saharan Africa. OBJECTIVE: To assess determinants of normal haemoglobin concentration among under-five children in SSA. DESIGN: Cross-sectional study design using a positive deviance approach SETTING: 33 SSA countries. PARTICIPANTS: 129 408 children aged 6-59 months PRIMARY AND SECONDARY OUTCOME MEASURES: A multilevel Poisson regression model with robust variance was fitted to identify determinants of normal haemoglobin concentration. An adjusted prevalence ratio with a 95% CI was reported to declare the statistical significance. RESULT: The pooled prevalence of normal haemoglobin concentration among under-five children in SSA was 34.9% (95% CI: 34.6% to 35.1%). High maternal education, middle and rich household wealth, female child, frequent antenatal care visits, non-anaemic mothers, taking anthelmintic drugs and normal nutritional status were associated with increased odds of normal haemoglobin concentration. On the other hand, higher birth order, having fever and diarrhoea, rural residence were associated with lower odds of normal haemoglobin levels. CONCLUSION: According to our finding, only four out of 10 under-five children in SSA had a normal haemoglobin level. This finding proved that anaemia among children in SSA remains a serious public health concern. Therefore, improving maternal education, provision of drugs for an intestinal parasite and early detection and treatment of maternal anaemia, febrile illness and diarrhoeal disease is important.

摘要

背景:儿童血红蛋白水平低与包括发育迟缓在内的短期和长期后果相关。在全球范围内,超过半数的五岁以下儿童血红蛋白浓度低。然而,关于撒哈拉以南非洲五岁以下儿童正常血红蛋白浓度的患病率及其决定因素的研究有限。 目的:评估撒哈拉以南非洲五岁以下儿童正常血红蛋白浓度的决定因素。 设计:采用正向偏差法的横断面研究设计 地点:33个撒哈拉以南非洲国家 参与者:129408名6至59个月大的儿童 主要和次要观察指标:采用具有稳健方差的多水平泊松回归模型来确定正常血红蛋白浓度的决定因素。报告调整后的患病率比值及95%置信区间以说明统计学显著性。 结果:撒哈拉以南非洲五岁以下儿童正常血红蛋白浓度的合并患病率为34.9%(95%置信区间:34.6%至35.1%)。母亲受教育程度高、家庭财富处于中等和富裕水平、女童、产前检查次数频繁、母亲无贫血、服用驱虫药以及营养状况正常与正常血红蛋白浓度的几率增加相关。另一方面,出生顺序较高、患有发热和腹泻、居住在农村与正常血红蛋白水平的几率较低相关。 结论:根据我们的研究结果,撒哈拉以南非洲每10名五岁以下儿童中只有4名血红蛋白水平正常。这一发现证明,撒哈拉以南非洲儿童贫血仍然是一个严重的公共卫生问题。因此,提高母亲受教育程度、提供治疗肠道寄生虫的药物以及早期发现和治疗母亲贫血、发热性疾病和腹泻病很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e7f/11043768/a7de5ddbce60/bmjopen-2023-074477f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e7f/11043768/a7de5ddbce60/bmjopen-2023-074477f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e7f/11043768/a7de5ddbce60/bmjopen-2023-074477f01.jpg

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本文引用的文献

[1]
Individual-and community-level factors associated with anemia among children aged 6-23 months in sub-Saharan Africa: evidence from 32 sub-Saharan African countries.

Arch Public Health. 2022-8-6

[2]
Prevalence and determinants of severity levels of anemia among children aged 6-59 months in sub-Saharan Africa: A multilevel ordinal logistic regression analysis.

PLoS One. 2021

[3]
Complementary feeding practices among mothers of children aged six months to two years at Children's hospital Lahore.

J Pak Med Assoc. 2020-9

[4]
Determinants of normal haemoglobin concentration among children in Ghana: a positive deviance analysis of nationally representative cross-sectional survey data.

Sci Rep. 2020-4-28

[5]
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PLoS One. 2019-7-3

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Ann N Y Acad Sci. 2019-4-22

[7]
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Front Pediatr. 2019-2-7

[8]
The Effect of Deworming School Children on Anemia Prevalence: A Systematic Review and Meta-Analysis.

Open Nurs J. 2018-7-31

[9]
Individual, maternal and household risk factors for anaemia among young children in sub-Saharan Africa: a cross-sectional study.

BMJ Open. 2018-5-14

[10]
Prevalence and risk factors of anemia in children.

J Pediatr (Rio J). 2016

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