Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Neurology, University of Florida College of Medicine, Miami, FL, USA.
J Alzheimers Dis. 2024;99(1):101-103. doi: 10.3233/JAD-240328.
The following commentary discusses a review by Cressot et al. entitled: 'Psychosis in Neurodegenerative Dementias: A Systematic Comparative Review'. The authors describe the epidemiology and phenomenology of psychosis across neurodegenerative dementias. Dementia with Lewy bodies had the highest reported prevalence of psychosis at 74% followed by Alzheimer's disease, 54% and frontotemporal degeneration, 42%. Detailed characterization of psychosis shows differences in the types of hallucinations and delusions by dementia type. These findings suggest that different types of dementia related pathology are associated with high rates of psychosis with more specific symptom profiles than previously appreciated. Understanding the differences and variety of psychotic experiences across dementia types may have diagnostic and therapeutic implications for treating hallucinations and delusions in populations suffering from neurodegenerative diseases.
以下评论讨论了 Cressot 等人题为“神经退行性痴呆中的精神病：系统比较综述”的评论。作者描述了神经退行性痴呆中精神病的流行病学和表现。路易体痴呆的精神病报告患病率最高，为 74%，其次是阿尔茨海默病，为 54%，额颞叶变性，为 42%。对精神病的详细特征分析表明，不同类型的痴呆症的幻觉和妄想类型存在差异。这些发现表明，与以前认为的相比，不同类型的与痴呆相关的病理学与精神病的高发生率相关，并具有更特定的症状特征。了解不同类型痴呆症中精神病体验的差异和多样性可能对治疗患有神经退行性疾病的人群的幻觉和妄想具有诊断和治疗意义。
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