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超重、肥胖和年龄是当前墨西哥人群心血管风险聚集的主要决定因素:FRIMEX III研究。

Overweight, Obesity, and Age Are the Main Determinants of Cardiovascular Risk Aggregation in the Current Mexican Population: The FRIMEX III Study.

作者信息

Meaney Eduardo, Pérez-Robles Enrique, Ortiz-Flores Miguel, Perez-Ishiwara Guillermo, Meaney Alejandra, Munguía Levy, Roman Gisele, Nájera Nayelli, Ceballos Guillermo

机构信息

Laboratorio de Investigación Cardiometabólica Integral, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City 11340, Mexico.

Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City 07320, Mexico.

出版信息

J Clin Med. 2024 Apr 12;13(8):2248. doi: 10.3390/jcm13082248.

Abstract

: The Mexican population exhibits several cardiovascular risk factors (CVRF) including high blood pressure (HBP), dysglycemia, dyslipidemia, overweight, and obesity. This study is an extensive observation of the most important CVFRs in six of the most populated cities in Mexico. : In a cohort of 297,370 participants (54% female, mean age 43 ± 12.6 years), anthropometric (body mass index (BMI)), metabolic (glycemia and total cholesterol (TC)), and blood pressure (BP) data were obtained. : From age 40, 40% and 30% of the cohort's participants were overweight or obese, respectively. HBP was found in 27% of participants. However, only 8% of all hypertensive patients were controlled. Fifty percent of the subjects 50 years and older were hypercholesterolemic. Glycemia had a constant linear relation with age. BMI had a linear correlation with SBP, glycemia, and TC, with elevated coefficients in all cases and genders. The β1 coefficient for BMI was more significant in all equations than the other β, indicating that it greatly influences the other CVRFs. : TC, glycemia, and SBP, the most critical atherogenic factors, are directly related to BMI.

摘要

墨西哥人群存在多种心血管危险因素(CVRF),包括高血压(HBP)、血糖异常、血脂异常、超重和肥胖。本研究对墨西哥人口最多的六个城市中最重要的心血管危险因素进行了广泛观察。

在一个由297370名参与者组成的队列中(54%为女性,平均年龄43±12.6岁),获取了人体测量数据(体重指数(BMI))、代谢数据(血糖和总胆固醇(TC))以及血压(BP)数据。

从40岁起,该队列中分别有40%和30%的参与者超重或肥胖。27%的参与者患有高血压。然而,所有高血压患者中只有8%的血压得到控制。50岁及以上的受试者中有50%患有高胆固醇血症。血糖与年龄呈持续线性关系。BMI与收缩压、血糖和TC呈线性相关,在所有情况和性别中系数均升高。BMI的β1系数在所有方程中比其他β系数更显著,表明它对其他心血管危险因素有很大影响。

TC、血糖和收缩压是最关键的致动脉粥样硬化因素,与BMI直接相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96a8/11051286/e3a0953ad760/jcm-13-02248-g001.jpg

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