Lee Dongun, Hong Jeong Hee
Department of Health Sciences and Technology, GAIHST (Gachon Advanced Institute for Health Sciences and Technology), Lee Gil Ya Cancer and Diabetes Institute, Gachon University, 155 Getbeolro, Yeonsu-gu, Incheon 21999, Republic of Korea.
Int J Mol Sci. 2024 Apr 10;25(8):4190. doi: 10.3390/ijms25084190.
Solute carrier family 26 member 4 (SLC26A4) is a member of the SLC26A transporter family and is expressed in various tissues, including the airway epithelium, kidney, thyroid, and tumors. It transports various ions, including bicarbonate, chloride, iodine, and oxalate. As a multiple-ion transporter, SLC26A4 is involved in the maintenance of hearing function, renal function, blood pressure, and hormone and pH regulation. In this review, we have summarized the various functions of SLC26A4 in multiple tissues and organs. Moreover, the relationships between SLC26A4 and other channels, such as cystic fibrosis transmembrane conductance regulator, epithelial sodium channel, and sodium chloride cotransporter, are highlighted. Although the modulation of SLC26A4 is critical for recovery from malfunctions of various organs, development of specific inducers or agonists of SLC26A4 remains challenging. This review contributes to providing a better understanding of the role of SLC26A4 and development of therapeutic approaches for the SLC26A4-associated hearing loss and SLC26A4-related dysfunction of various organs.
溶质载体家族26成员4（SLC26A4）是SLC26A转运蛋白家族的成员，在包括气道上皮、肾脏、甲状腺和肿瘤在内的多种组织中表达。它转运多种离子，包括碳酸氢根、氯离子、碘和草酸盐。作为一种多离子转运蛋白，SLC26A4参与听力功能、肾功能、血压以及激素和pH调节的维持。在本综述中，我们总结了SLC26A4在多种组织和器官中的各种功能。此外，还重点介绍了SLC26A4与其他通道之间的关系，如囊性纤维化跨膜传导调节因子、上皮钠通道和氯化钠共转运体。尽管SLC26A4的调节对于各种器官功能障碍的恢复至关重要，但开发SLC26A4的特异性诱导剂或激动剂仍然具有挑战性。本综述有助于更好地理解SLC26A4的作用，并为与SLC26A4相关的听力损失和各种器官的SLC26A4相关功能障碍开发治疗方法。
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