School of Chemistry and Chemical Engineering, Henan University of Technology, Locus Street, High-Tech Industry Development Zone, Zhengzhou, 450001, Henan, China.
Protein J. 2024 Jun;43(3):464-476. doi: 10.1007/s10930-024-10200-5. Epub 2024 Apr 27.
The development of peptide-based materials is one of the most challenging aspects of biomaterials research in recent years. The assembly of peptides is mainly controlled by forces such as hydrogen bonding, hydrophobic interaction, electrostatic interaction, and π-π accumulation. Peptides have unique advantages such as simple structure, easy synthesis, good biocompatibility, non-toxicity, easy modification, etc. These factors make peptides turn into ideal biomedical materials, and they have a broad application prospect in biomedical materials, and thus have received wide attention. In this review, the mechanism and classification of peptide self-assembly and its applications in biomedicine and hydrogels were introduced.
肽基材料的发展是近年来生物材料研究中最具挑战性的方面之一。肽的组装主要受氢键、疏水相互作用、静电相互作用和π-π堆积等力的控制。肽具有结构简单、合成容易、良好的生物相容性、无毒、易修饰等独特优势。这些因素使肽成为理想的生物医学材料，在生物医学材料中有广阔的应用前景，因此受到广泛关注。本文综述了肽自组装的机制和分类及其在生物医学和水凝胶中的应用。
