Department of Ophthalmology, Zaozhuang Municipal Hospital (L.L.), Zaozhuang, Shandong, China.
From the Department of Ophthalmology, The Second Affiliated Hospital of Dalian Medical University (X.W., C.L., S.W., X.W.), Dalian, Liaoning, China.
Am J Ophthalmol. 2024 Sep;265:176-188. doi: 10.1016/j.ajo.2024.04.021. Epub 2024 Apr 26.
To assess the incidence of secondary glaucoma in children following congenital cataract surgery.
Systematic review and meta-analysis.
The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through March 16, 2023. Studies reporting congenital cataract surgery and glaucoma were enrolled. The quality of the selected studies was assessed using the Newcastle Ottawa Scale, and data analysis was executed utilizing R software.
A total of 36 published studies with 3151 patients (4717 eyes) were included in the analysis. The incidence rate of glaucoma following congenital cataract surgery was 6.6% (95% CI: 3.9%, 9.9%). The incidence of secondary glaucoma in the primary intraocular lens (IOL) implantation group (3.3% [95% CI: 1.5%, 5.8%]) and the secondary IOL implantation group (3.5% [95% CI: 0%, 11.4%]) were lower compared to the aphakia group (13.5% [95% CI: 7.7%, 20.6%]). The incidence rate among children with congenital cataracts from Asia (6.9% [95% CI: 4.1%, 10.4%]) was higher than that in European children (0.9% [95% CI: 0%, 3.0%]; P < .01). A correlation was identified between the age at cataract surgery and the incidence of secondary glaucoma (P = .02).
This meta-analysis found that the incidence of secondary glaucoma following congenital cataract surgery is approximately 6.6%. Children with IOL implantation exhibit a lower incidence of secondary glaucoma, with a lower incidence noted in European children compared to their Asian counterparts. The age at cataract surgery is an important risk factor to consider.
评估先天性白内障手术后儿童继发性青光眼的发生率。
系统评价和荟萃分析。
检索 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库，检索时间截至 2023 年 3 月 16 日。纳入报告先天性白内障手术和青光眼的研究。使用纽卡斯尔-渥太华量表评估入选研究的质量，并使用 R 软件进行数据分析。
共纳入 36 项已发表的研究，包含 3151 例患者（4717 只眼）。先天性白内障手术后青光眼的发生率为 6.6%（95%CI：3.9%，9.9%）。一期人工晶状体（IOL）植入组（3.3%[95%CI：1.5%，5.8%]）和二期 IOL 植入组（3.5%[95%CI：0%，11.4%]）继发性青光眼的发生率低于无晶状体组（13.5%[95%CI：7.7%，20.6%]）。亚洲先天性白内障患儿（6.9%[95%CI：4.1%，10.4%]）的发生率高于欧洲患儿（0.9%[95%CI：0%，3.0%]；P<.01）。白内障手术年龄与继发性青光眼的发生率之间存在相关性（P=0.02）。
本荟萃分析发现，先天性白内障手术后继发性青光眼的发生率约为 6.6%。植入 IOL 的儿童发生继发性青光眼的风险较低，欧洲儿童的发生率低于亚洲儿童。白内障手术的年龄是一个重要的考虑因素。
