β-淀粉样蛋白是一种 Kinocidin 细胞因子。

β-Amyloid Is a Kinocidin Cytokine.

机构信息

Krembil Research Institute, University Health Network, Dept. of Chemistry, University of Toronto, 60 Leonard Avenue, Toronto, Ontario M5T 0S8, Canada.

出版信息

ACS Chem Neurosci. 2024 May 15;15(10):1948-1950. doi: 10.1021/acschemneuro.4c00236. Epub 2024 Apr 29.

DOI:10.1021/acschemneuro.4c00236

PMID:38684014

Abstract

Although β-amyloid (Aβ) has long been studied as a key contributor to the pathology of Alzheimer's disease (AD), its physiological role (if any) remains undetermined. This Viewpoint highlights the evolving concept that if AD is an immunopathic disorder then Aβ may be an immunopeptide. The identification of Aβ as an immunopeptide is further refined to it being a kinocidin, a subtype of cytokine with antimicrobial activity.

摘要

虽然β-淀粉样蛋白（Aβ）长期以来一直被研究为阿尔茨海默病（AD）病理的关键贡献者，但它的生理作用（如果有的话）仍然不确定。本观点强调了这样一种不断发展的概念，即如果 AD 是一种免疫病理疾病，那么 Aβ 可能是一种免疫肽。将 Aβ 确定为免疫肽的进一步细化是将其确定为具有抗菌活性的细胞因子亚型——kinocidin。