Numerous studies have characterized the critical role of circular RNAs (circRNAs) as regulatory factors in the progression of multiple cancers. However, the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma (UM) remain enigmatic. In this study, we identified a novel circRNA, , through re-analysis of UM microarray data and quantitative RT-PCR. was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both and settings. Mechanistically, was observed to bind to the KH1 and KH2 domains of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), thereby enhancing the function of IGF2BP3 by stabilizing its target mRNA. RNA sequencing assays identified () as a target gene of and IGF2BP3 at the transcriptional level. Rescue assays demonstrated that exerts its biological function by stabilizing mRNA and regulating the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway. Collectively, may promote UM progression by stabilizing mRNA and activating the MAPK/ERK signaling pathway through the formation of a /IGF2BP3/ RNA-protein ternary complex, thus providing a potential biomarker and therapeutic target for UM.