Gökgöz Özışık Gülce, Eker Buyuksireci Dilek, Şahin Tayfun, Caglıyan Turk Ayla
Department of Ophthalmology, Faculty of Medicine, Hitit University, Corum, Turkey.
Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Hitit University, Corum, Turkey.
Ocul Immunol Inflamm. 2025 Jan;33(1):40-47. doi: 10.1080/09273948.2024.2345289. Epub 2024 May 1.
To evaluate the choroidal vascularity index and choroidal thickness in patients with rheumatoid arthritis.
This study is a case control study. Our study consists of a total of two groups, with 32 individuals diagnosed with rheumatoid arthritis (RA) and 32 healthy volunteers. The thickness of the subfoveal choroid was measured from the 500 micron (µm), 1000 µm, 1500 µm nasal aspect of the fovea, and 500µm, 1000µm, 1500 µm temporal and subfoveal thickness of the fovea. ImageJ version 1.53i (National Institutes of Health, Bethesda, MD, USA) from open access was used for choroidal vascular index calculation.
The mean age ( = 0.064) and gender distribution ( = 0.522) were not statistically different between these two groups. There was no difference between the groups in terms of visual acuity ( = 0.060), intraocular pressures (=0.056), refractive errors ( = 0.418), and axial lengths ( = 0.280). Temporal 500 µm CT ( = 0.038), temporal 1000 µm CT ( = 0.010), and temporal 1500 µm CT ( = 0.005) differed significantly between the groups. The luminal area was significantly different between the RA group (842.71 ± 192.77) and the control group (957.78 ± 230.83) ( = 0.034). The choroidal vascularity index showed a significant difference between the RA group (64.99 ± 4.71) and the control group (67.34 ± 3.40) ( = 0.026). A significant difference was observed between the seronegative RA and the control group with temporal 1500 µm CT ( = 0.030), temporal 1000 µm CT ( = 0.023), and luminal area ( = 0.034).
We demonstrated thinning in CT and decreased CVI for the first time in RA patients by comparing it with the control group.
评估类风湿关节炎患者的脉络膜血管指数和脉络膜厚度。
本研究为病例对照研究。我们的研究共分为两组，32例被诊断为类风湿关节炎（RA）的患者和32名健康志愿者。从中央凹鼻侧500微米（µm）、1000 µm、1500 µm处以及中央凹颞侧500µm、1000µm、1500 µm处测量中央凹下脉络膜的厚度以及中央凹下厚度。使用来自开放获取的ImageJ 1.53i版本（美国国立卫生研究院，马里兰州贝塞斯达）计算脉络膜血管指数。
两组之间的平均年龄（=0.064）和性别分布（=0.522）无统计学差异。两组在视力（=0.060）、眼压（=0.056）、屈光不正（=0.418）和眼轴长度（=0.280）方面无差异。两组之间颞侧500 µm脉络膜厚度（=0.038）、颞侧1000 µm脉络膜厚度（=0.010）和颞侧1500 µm脉络膜厚度（=0.005）存在显著差异。RA组（842.71±192.77）和对照组（957.78±230.83）的管腔面积存在显著差异（=0.034）。RA组（64.99±4.71）和对照组（67.34±3.40）的脉络膜血管指数存在显著差异（=0.026）。在颞侧1500 µm脉络膜厚度（=0.030）、颞侧1000 µm脉络膜厚度（=0.023）和管腔面积（=0.034）方面，血清阴性RA组与对照组之间存在显著差异。
通过与对照组比较，我们首次在RA患者中证明了脉络膜厚度变薄和脉络膜血管指数降低。
