Department of Informatics and Computing, Faculty of Engineering, Universidad Tecnológica Metropolitana, Santiago, Chile.
Center for Biomedical Imaging, the Radiology Department, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Med Eng Phys. 2024 May;127:104170. doi: 10.1016/j.medengphy.2024.104170. Epub 2024 Apr 12.
Recently, functional Near-Infrared Spectroscopy (fNIRS) was applied to obtain, non-invasively, the human peri‑spinal Neuro-Vascular Response (NVR) under a non-noxious electrical stimulation of a peripheral nerve. This method allowed the measurements of changes in the concentration of oxyhemoglobin (OHb) and deoxyhemoglobin (HHb) from the peri‑spinal vascular network. However, there is a lack of clarity about the potential differences in perispinal NVR recorded by the different fNIRS technologies currently available. In this work, the two main noninvasive fNIRS technologies were compared, i.e., LED and LASER-based. The recording of the human peri‑spinal NVR induced by non-noxious electrical stimulation of a peripheral nerve was recorded simultaneously at C and T vertebral levels. The amplitude, rise time, and full width at half maximum duration of the perispinal NVRs were characterized in healthy volunteers and compared between both systems. The main difference was that the LED-based system shows about one order of magnitude higher values of amplitude than the LASER-based system. No statistical differences were found for rise time and for duration parameters (at thoracic level). The comparison of point-to-point wave patterns did not show significant differences between both systems. In conclusion, the peri‑spinal NRV response obtained by different fNIRS technologies was reproducible, and only the amplitude showed differences, probably due to the power of the system which should be considered when assessing the human peri‑spinal vascular network.
最近，功能近红外光谱（fNIRS）技术被应用于在周围神经非伤害性电刺激下，非侵入式地获取人类脊柱周围神经血管反应（NVR）。该方法允许测量脊柱周围血管网络中氧合血红蛋白（OHb）和脱氧血红蛋白（HHb）浓度的变化。然而，目前可用的不同 fNIRS 技术记录的脊柱周围 NVR 之间的潜在差异尚不清楚。在这项工作中，比较了两种主要的非侵入性 fNIRS 技术，即基于 LED 和基于 LASER 的技术。同时在 C 和 T 椎骨水平记录非伤害性周围神经电刺激引起的人类脊柱周围 NVR。在健康志愿者中对脊柱周围 NVR 的幅度、上升时间和半最大值全宽进行了特征描述，并在两种系统之间进行了比较。主要区别在于，基于 LED 的系统显示的幅度值比基于 LASER 的系统高约一个数量级。上升时间和持续时间参数（在胸椎水平）没有统计学差异。两种系统之间的逐点波型比较没有显示出显著差异。总之，不同 fNIRS 技术获得的脊柱周围 NRV 反应具有可重复性，只有幅度显示出差异，这可能是由于系统的功率不同，在评估人类脊柱周围血管网络时应考虑这一因素。
