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支化聚缩水甘油醚的生物相容性和内皮通透性：由缩水甘油与 B(CF) 在干燥和湿润条件下开环聚合生成。

Biocompatibility and Endothelial Permeability of Branched Polyglycidols Generated by Ring-Opening Polymerization of Glycidol with B(CF) under Dry and Wet Conditions.

机构信息

Donostia International Physics Center (DIPC), Paseo Manuel Lardizábal 4, Donostia-San Sebastián, 20018, Spain.

Centro de Física de Materiales, CSIC-UPV/EHU, Paseo Manuel Lardizábal 5, Donostia-San Sebastián, 20018, Spain.

出版信息

Biomacromolecules. 2024 Jun 10;25(6):3583-3595. doi: 10.1021/acs.biomac.4c00210. Epub 2024 May 4.

DOI:10.1021/acs.biomac.4c00210
PMID:38703359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11170947/
Abstract

Polyglycidol or polyglycerol (PG), a polyether widely used in biomedical applications, has not been extensively studied in its branched cyclic form (PG), despite extensive research on hyperbranched PG (HPG). This study explores the biomedical promise of PG, particularly its ability to cross the blood-brain barrier (BBB). We evaluate biocompatibility, endothelial permeability, and formation of branched linear PG (PG) as topological impurities in the presence of water. Small angle X-ray scattering in solution revealed a fractal dimension of approximately two for PG and the mixture PG, suggesting random branching. Comparisons of cytotoxicity and endothelial permeability between PG, PG, and HPG in a BBB model using hCMEC/D3 cells showed different biocompatibility profiles and higher endothelial permeability for HPG. PG showed a tendency to accumulate around cell nuclei, in contrast to the behavior of HPG. This study contributes to the understanding of the influence of polymer topology on biological behavior.

摘要

聚甘油或聚丙二醇（PG）是一种广泛应用于生物医学领域的多醚，尽管对超支化 PG（HPG）进行了广泛的研究，但对其支化环状形式（PG）的研究却相对较少。本研究探讨了 PG 在生物医学方面的应用前景，特别是其穿过血脑屏障（BBB）的能力。我们评估了 PG 在水中的生物相容性、内皮通透性和支化线性 PG（PG）的形成情况。溶液中的小角度 X 射线散射表明 PG 和 PG 混合物的分形维数约为 2，表明存在随机分支。在使用 hCMEC/D3 细胞的 BBB 模型中，PG、PG 和 HPG 的细胞毒性和内皮通透性比较表明，HPG 的生物相容性和内皮通透性更高。PG 有在细胞核周围聚集的趋势，而 HPG 则没有。这项研究有助于了解聚合物拓扑结构对生物行为的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2c8/11170947/5639904910e3/bm4c00210_0011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2c8/11170947/357b9140aa83/bm4c00210_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f2c8/11170947/5639904910e3/bm4c00210_0011.jpg

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
Activated Monomer Mechanism (AMM) in Cationic Ring-Opening Polymerization. The Origin of the AMM and Further Development in Polymerization of Cyclic Esters.

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[8]
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[9]
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[10]
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