Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Biomed Pharmacother. 2024 Jun;175:116608. doi: 10.1016/j.biopha.2024.116608. Epub 2024 May 3.
Recent advances in metagenomic testing opened a new window into the mammalian blood virome. Comprised of well-known viruses like human immunodeficiency virus, hepatitis C virus, and hepatitis B virus, the virome also includes many other eukaryotic viruses and phages whose medical significance, lifecycle, epidemiology, and impact on human health are less well known and thus regarded as commensals. This review synthesizes available information for the so-called commensal virome members that circulate in the blood of humans considering their restriction to and interaction with the human host, their natural history, and their impact on human health and physiology.
近年来,宏基因组检测技术的进步为研究哺乳动物血液病毒组打开了一扇新的窗口。病毒组包括人类免疫缺陷病毒、丙型肝炎病毒和乙型肝炎病毒等知名病毒,还包括许多其他真核病毒和噬菌体,其医学意义、生命周期、流行病学以及对人类健康的影响尚不清楚,因此被视为共生体。本综述综合了在考虑到其对人类宿主的限制和相互作用、自然史以及对人类健康和生理学影响的情况下,在人类血液中循环的所谓共生病毒组成员的现有信息。