INTRODUCTION

This longitudinal study was based on the outcomes of Donor Lymphocyte Infusion (DLI) for falling peripheral blood (PB) CD34 and CD3 donor chimerism (DC).

METHODS

From 2012 to 2018, data was collected from the BMT database and electronic medical records (EMR). The primary objective was to compare the indication for DLI based on falling PB CD34 or CD3 DC in patients post allo-SCT for AML and MDS and their overall survival (OS).

RESULTS

18/70 patients met the inclusion criteria. Indications for DLI were i) falling PB CD34 DC ≤ 80 % with morphological relapse, ii) falling PB CD34 DC ≤ 80 % without morphological relapse and iii) falling PB CD3 DC ≤ 80 % without falling PB CD34 DC. Log rank analysis showed falling PB CD34 DC and morphological relapse had significantly lower OS. Linear regression demonstrated better OS post DLI if there was PB CD34 and CD3 chimerism response at 30 days (p = 0.029), GVHD (p = 0.032) and tapering immunosuppression at the time of falling DC (p = 0.042).

CONCLUSION

DLI for PB CD34 DC values ≤ 80 % and morphological relapse had the lowest OS. In this study, full DC was achieved after DLI even with a PB CD3DC value as low as 13 %, provided the PB CD34 DC remained > 80 %. Further research is vital in CD34 DC as a biomarker for disease relapse and loss of engraftment.