Ganeshan Srivathsan, Parihar Nidhi, Chonzom Donker, Mohanakrishnan Dinesh, Das Rajdeep, Sarma Dandadhar, Gogoi Devipriya, Das Manash Ranjan, Upadhayula Suryanarayana Murty, Pemmaraju Deepak Bharadwaj
Department of Pharmacology & Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, 781101, Assam, India.
Department of Zoology, Gauhati University, Guwahati, 781014, Assam, India.
Drug Deliv Transl Res. 2024 Oct;14(10):2727-2742. doi: 10.1007/s13346-024-01594-x. Epub 2024 May 4.
Acne Vulgaris or Acne is a multifactorial bacterial infection caused by Propionibacterium acne, leading to inflammation and decreased quality of life, especially in adolescence. Currently, antibiotics and retinoids are preferred for treating acne. However, their continuous usage may lead to anti-microbial resistance and other side effects. Therefore, research on developing effective strategies to reduce antimicrobial resistance and improve acne healing is ongoing. The current work reports the synthesis and evaluation of near-infrared light-absorbing copper sulfide (CuS) nanoparticles loaded with a biomolecule, Glycyrrhizin (Ga). The photothermal efficacy studies, and in-vitro and in-vivo experiments indicated that the Ga-CuS NPs generated localized hyperthermia in acne-causing bacteria, leading to their complete growth inhibition. The results indicated that the Ga-Cus NPs possess excellent antibacterial and anti-inflammatory properties in the acne and inflammatory models. This could be from the synergistic effect of CuS NPs mediated mild Photothermal effect and inherent pharmacological properties of Ga. Further detailed studies of the formulations can pave the way for application in cosmetic clinics for the effective and minimally invasive management of Acne-like conditions.
寻常痤疮或痤疮是一种由痤疮丙酸杆菌引起的多因素细菌感染，会导致炎症并降低生活质量，尤其是在青少年时期。目前，抗生素和维甲酸类药物是治疗痤疮的首选。然而，持续使用这些药物可能会导致抗菌耐药性和其他副作用。因此，正在进行开发有效策略以降低抗菌耐药性并改善痤疮愈合的研究。当前的工作报道了负载生物分子甘草酸（Ga）的近红外光吸收硫化铜（CuS）纳米颗粒的合成与评估。光热效应研究以及体外和体内实验表明，Ga-CuS纳米颗粒在引起痤疮的细菌中产生局部高温，导致其完全生长抑制。结果表明，Ga-CuS纳米颗粒在痤疮和炎症模型中具有优异的抗菌和抗炎特性。这可能源于CuS纳米颗粒介导的温和光热效应与Ga的固有药理特性的协同作用。对这些制剂的进一步详细研究可为在美容诊所有效且微创管理痤疮样病症的应用铺平道路。
