帕金森病患者中淡漠和冲动控制障碍的共病情况：多种测量方法的差异。
Co-Occurrence of Apathy and Impulse Control Disorders in Parkinson Disease: Variation across Multiple Measures.
机构信息
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
出版信息
Arch Clin Neuropsychol. 2024 Oct 25;39(7):907-913. doi: 10.1093/arclin/acae036.
OBJECTIVE
To determine if the co-occurrence of apathy and impulse control disorders (ICDs) in Parkinson disease is dependent on instrument selection and assess the concurrent validity of three motivation measures by examining interrelationships between them.
METHOD
Ninety-seven cognitively normal individuals with idiopathic Parkinson disease (PD) completed the Questionnaire for Impulsive-Compulsive Disorders in Parkinson Disease-Rating Scale (QUIP-RS) and three apathy measures: the Apathy Scale, Lille Apathy Rating Scale, and Item 4 of the Movement Disorder Society-Unified Parkinson Disease Rating Scale.
RESULTS
Fifty (51.5%) participants were classified as apathetic on at least one measure, and only four individuals (4.3%) obtained clinically elevated scores on all three measures. The co-occurrence of apathy and ICD varied across measures.
CONCLUSIONS
We observed a co-occurrence of apathy and ICDs in PD patients with each apathy instrument; however, limited concurrent validity exists across measures. This is important for future investigations into shared pathophysiology and the design of future clinical trials aimed at improving the early detection and treatment of these debilitating syndromes.
目的
确定帕金森病中淡漠和冲动控制障碍（ICD）的同时发生是否依赖于仪器选择，并通过检查它们之间的相互关系来评估三种动机测量方法的同时效度。
方法
97 名认知正常的特发性帕金森病（PD）患者完成了帕金森病冲动-强迫障碍问卷评定量表（QUIP-RS）和三种淡漠量表：淡漠量表、里尔淡漠评定量表和运动障碍协会统一帕金森病评定量表第 4 项。
结果
50 名（51.5%）参与者在至少一项测量中被归类为淡漠，只有 4 名个体（4.3%）在所有三项测量中获得了临床显著得分。淡漠和 ICD 的同时发生在不同的测量方法中存在差异。
结论
我们观察到在帕金森病患者中，每种淡漠仪器都存在淡漠和 ICD 的同时发生；然而，在测量方法之间存在有限的同时效度。这对于未来对共病生理机制的研究以及旨在改善这些使人衰弱的综合征的早期检测和治疗的未来临床试验的设计都很重要。
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